Protein Information

Name CYP1A1
Synonyms AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1…

Compound Information

Name methoxychlor
CAS 1,1′-(2,2,2-trichloroethylidene)bis[4-methoxybenzene]

Reference List

PubMed Abstract RScore(About this table)
17654248 Han EH, Jeong TC, Jeong HG: Methoxychlor suppresses the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1A1 expression in murine Hepa-1c1c7 cells. J Toxicol Environ Health A. 2007 Aug;70(15-16):1304-9.
85(1,1,1,5) Details
12919727 Oropeza-Hernandez LF, Lopez-Romero R, Albores A: Hepatic CYP1A, 2B, 2C, 2E and 3A regulation by methoxychlor in male and female rats. Toxicol Lett. 2003 Sep 15;144(1):93-103.

Males showed the greatest increases of ethoxy- and methoxyresorufin-O-dealkylase (EROD and MROD, respectively), two CYP1A1/1A2-related activities.
2(0,0,0,2) Details
12167570 Hu Y, Kupfer D: Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel catechol metabolite. Drug Metab Dispos. 2002 Sep;30(9):1035-42.

0(0,0,0,0) Details
16280380 Symonds DA, Miller KP, Tomic D, Flaws JA: Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium. Toxicol Sci. 2006 Feb;89(2):510-4. Epub 2005 Nov 9.

0(0,0,0,0) Details
9736480 Li HC, Kupfer D: Mechanism of induction of rat hepatic CYP2B and 3A by the pesticide methoxychlor. J Biochem Mol Toxicol. 1998;12(6):315-23.

0(0,0,0,0) Details
9047321 Stresser DM, Kupfer D: Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. Biochemistry. 1997 Feb 25;36(8):2203-10.

0(0,0,0,0) Details
7595932 Li HC, Dehal SS, Kupfer D: Induction of the hepatic CYP2B and CYP3A enzymes by the proestrogenic pesticide methoxychlor and by DDT in the rat. J Biochem Toxicol. 1995 Feb;10(1):51-61.

0(0,0,0,0) Details