Protein Information

Name SP1
Synonyms CER 2; SP1; CRL2; CER2; CKTSF1B3; COCO; CRL 2; DAND 5…

Compound Information

Name benzalkonium chloride
CAS quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Reference List

PubMed Abstract RScore(About this table)
2440265 Piotrowski W, Mead M, Foreman JC: Action of the SP2-11 and SP3-11 fragments of substance P on rat peritoneal mast cells. Agents Actions. 1987 Apr;20(3-4):178-80.

Benzalkonium chloride was found to be a competitive antagonist of SP and SP3-11: the dissociation constants for the benzalkonium chloride-receptor interaction being about the same when either SP1-11 or SP3-11 was used as the agonist.
33(0,1,1,3) Details
2444699 Repke H, Piotrowski W, Bienert M, Foreman JC: Histamine release induced by Arg-Pro-Lys-Pro (CH2) 11CH3 from rat peritoneal mast cells. J Pharmacol Exp Ther. 1987 Oct;243(1):317-21.

Unlike dodecylamine itself, SP1-4C12 induced noncytolytic histamine release which was inhibited by benzalkonium chloride and by the substance P antagonist [D-Pro4,D-Trp7,9,10] SP4-11.
34(0,1,1,4) Details