Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name fonofos
CAS

Reference List

PubMed Abstract RScore(About this table)
17705656 Nillos MG, Rodriguez-Fuentes G, Gan J, Schlenk D: Enantioselective acetylcholinesterase inhibition of the organophosphorous insecticides profenofos, fonofos, and crotoxyphos. Environ Toxicol Chem. 2007 Sep;26(9):1949-54.
197(2,3,3,7) Details
10732982 Hirashima A, Kuwano E, Eto M: Docking study of enantiomeric fonofos oxon bound to the active site of Torpedo californica acetylcholinesterase. Bioorg Med Chem. 2000 Mar;8(3):653-6.
193(2,3,3,3) Details
1581539 Maxwell DM, Brecht KM: Quantitative structure-activity analysis of acetylcholinesterase inhibition by oxono and thiono analogues of organophosphorus compounds. Chem Res Toxicol. 1992 Jan-Feb;5(1):66-71.

A comparison of the bimolecular rate constants (ki) for inhibition of electric eel acetylcholinesterase (AChE) by the oxono (i.e., P=O) and thiono (i.e., P=S) analogues of parathion, methylparathion, leptophos, fonofos, sarin, and soman revealed that the oxono/thiono ratios of ki values varied from 14 for soman to 1240 for parathion.
35(0,1,1,5) Details
3983973 Levi PE, Hodgson E: Oxidation of pesticides by purified cytochrome P-450 isozymes from mouse liver. Toxicol Lett. 1985 Feb-Mar;24(2-3):221-8.

The pesticides parathion, fonofos, DEF, Mocap and profenofos were oxidized by the reconstituted monooxygenase system to form acetylcholinesterase (AChE) inhibitors.
31(0,1,1,1) Details
2417385 Cohen SD, Williams RA, Killinger JM, Freudenthal RI: Comparative sensitivity of bovine and rodent acetylcholinesterase to in vitro inhibition by organophosphate insecticides. Toxicol Appl Pharmacol. 1985 Dec;81(3 Pt 1):452-9.

11(0,0,0,11) Details