| Name | interleukin 1 alpha |
|---|---|
| Synonyms | Hematopoietin 1; IL 1 alpha; IL 1A; IL1; IL1 alpha; IL1A; IL1F1; Interleukin 1 alpha… |
| Name | benzalkonium chloride |
|---|---|
| CAS | quaternary ammonium compounds, alkylbenzyldimethyl, chlorides |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8006454 | Wilmer JL, Burleson FG, Kayama F, Kanno J, Luster MI: Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin. J Invest Dermatol. 1994 Jun;102(6):915-22. Croton oil, benzalkonium chloride, and dinitrofluorobenzene induced the intracellular production of IL-1 alpha without a concomitant release into the medium. |
83(1,1,1,3) | Details |
| 8048060 | Muller-Decker K, Furstenberger G, Marks F: Keratinocyte-derived proinflammatory key mediators and cell viability as in vitro parameters of irritancy: a possible alternative to the Draize skin irritation test. Toxicol Appl Pharmacol. 1994 Jul;127(1):99-108. Using human keratinocytes, the measurement of proinflammatory eicosanoid and interleukin-1 alpha release and of the impairment of cell viability have provided a suitable in vitro/in vivo correlation for at least three surfactants. The in vitro study has been extended using structurally unrelated, pharmacologically relevant compounds including cyclohexanol, acrylamide, triethanolamine, Tween 80, benzalkonium chloride, NiSO4, SnCl2, and ZnCl2. |
2(0,0,0,2) | Details |
| 11886532 | Corsini E, Viviani B, Marinovich M, Galli CL: Cyclosporin A exacerbates skin irritation induced by tributyltin by increasing nuclear factor kappa B activation. J Invest Dermatol. 2001 Dec;117(6):1627-34. We previously demonstrated the involvement of interleukin-1 alpha and tumor necrosis factor alpha in tributyltin-induced skin irritation. On the other hand, under the same experimental conditions, cyclosporine A prevented the elicitation phase of oxazolone-induced contact allergy, but was ineffective in preventing benzalkonium-chloride-induced skin irritation. |
1(0,0,0,1) | Details |
| 9875300 | Muller-Decker K, Heinzelmann T, Furstenberger G, Kecskes A, Lehmann WD, Marks F: Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. Toxicol Appl Pharmacol. 1998 Nov;153(1):59-67. Benzalkonium chloride (BKCI) and (SLS) elicited erythema and caused increased transepidermal water loss, indicating a disturbance of the epidermal barrier. |
0(0,0,0,0) | Details |