Protein Information

Name guanylate cyclase
Synonyms AMDM; Natriuretic peptide receptor; ANP B; ANPRB; Atrial natriuretic peptide B type receptor; Atrial natriuretic peptide receptor B; Atrial natriuretic peptide receptor B precursor (ANP B) (ANPRB) (GC B) (Guanylate cyclase B); Atrionatriuretic peptide receptor B…

Compound Information

Name gibberellic acid
CAS (1α,2β,4aα,4bβ,10β)-2,4a,7-trihydroxy-1-methyl-8-methylenegibb-3-ene-1,10-dicarboxylic acid 1,4a-lactone

Reference List

PubMed Abstract RScore(About this table)
2859192 Vesely DL, Hudson JL, Pipkin JL Jr, Pack LD, Meiners SE: Plant growth-promoting hormones activate mammalian guanylate cyclase activity. Endocrinology. 1985 May;116(5):1887-92.

Thus, auxins (indole-3-acetic acid, indole-3-butyric acid, beta-naphthoxyacetic acid, and 2,4,5-trichlorophenoxy acetic acid), gibberellins (gibberellic acid), and cytokinins [N6-benzyl adenine, kinetin (6-furfuryl aminopurine), and beta-(2-furyl) acrylic acid] all increased rat lung, small intestine, liver, and renal cortex guanylate cyclase activity 2- to 4-fold at the 1 microM concentration.
9(0,0,1,4) Details
6104850 Vesely DL, Rochat MH: Gibberellic acid, a plant growth hormone, enhances mammalian guanylate cyclase activity. Res Commun Chem Pathol Pharmacol. 1980 Apr;28(1):123-32.
8(0,0,1,3) Details
20170981 Teng Y, Xu W, Ma M: cGMP is required for seed germination in Arabidopsis thaliana. J Plant Physiol. 2010 Feb 17.

We demonstrated that both, a membrane-permeant analogue of cGMP (8-Br-cGMP) and the cyclic nucleotide phosphodiesterase (PDE) inhibitor Tadalafil promoted A. thaliana seed germination, whereas the guanylate cyclase inhibitor LY 83583 (6-anilino-5,8-quinolinedione; LY) inhibited it.
LY blocked gibberellic acid (GA)-induced seed germination, whereas GA and 8-Br-cGMP co-treatment increased the germination rate and more effectively overcame LY-inhibition than 8-Br-cGMP alone.
1(0,0,0,1) Details