Protein Information

Name SLY1
Synonyms FKSG23; RA410; SCFD 1; SCFD1; SLY 1; SLY1; STXBP1L2; Sec1 family domain containing 1…

Compound Information

Name gibberellic acid
CAS (1α,2β,4aα,4bβ,10β)-2,4a,7-trihydroxy-1-methyl-8-methylenegibb-3-ene-1,10-dicarboxylic acid 1,4a-lactone

Reference List

PubMed Abstract RScore(About this table)
20083325 Dohmann EM, Nill C, Schwechheimer C: DELLA proteins restrain germination and elongation growth in Arabidopsis thaliana COP9 signalosome mutants. Eur J Cell Biol. 2010 Feb-Mar;89(2-3):163-8. Epub 2010 Jan 18.

Here, we examine the role of CSN in the context of the E3 ubiquitin ligase SCF (SLEEPY1 (SLY1)), which promotes gibberellic acid (GA)-dependent responses in Arabidopsis thaliana.
8(0,0,1,3) Details
12724538 McGinnis KM, Thomas SG, Soule JD, Strader LC, Zale JM, Sun TP, Steber CM: The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. Plant Cell. 2003 May;15(5):1120-30.


The Arabidopsis SLY1 (SLEEPY1) gene positively regulates gibberellin (GA) signaling.
6(0,0,0,6) Details
18077204 Schwechheimer C: Understanding gibberellic acid signaling--are we there yet? . Curr Opin Plant Biol. 2008 Feb;11(1):9-15.

The current view is that GA binds to a soluble GID1 receptor, which interacts with the DELLA repressor proteins in a GA-dependent manner and thereby induces DELLA protein degradation via the E3 ubiquitin ligase SCF (GID2/SLY1).
1(0,0,0,1) Details
9611170 Steber CM, Cooney SE, McCourt P: Isolation of the GA-response mutant sly1 as a suppressor of ABI1-1 in Arabidopsis thaliana. Genetics. 1998 Jun;149(2):509-21.

Thus, we postulate that SLY1 is a key factor in GA reception.
Seed dormancy and germination in higher plants are partially controlled by the plant hormones abscisic acid (ABA) and gibberellic acid (GA).
1(0,0,0,1) Details