Protein Information

Name N acetyltransferase
Synonyms AAC 2; NAT2; AAC2; ARY 2; ARY2; Arylamide acetylase 2; Arylamine N acetyltransferase 2; N acetyltransferase…

Compound Information

Name glufosinate
CAS 2-amino-4-(hydroxymethylphosphinyl)butanoic acid

Reference List

PubMed Abstract RScore(About this table)
10517854 Beriault JN, Horsman GP, Devine MD: Phloem transport of D,L-glufosinate and acetyl-L-glufosinate in glufosinate-resistant and -susceptible brassica napus. Plant Physiol. 1999 Oct;121(2):619-28.

Phloem transport of D,L-[(14) C] glufosinate, D-[(14) C] glufosinate, and acetyl-L-[(14) C] glufosinate was examined in the susceptible Brassica napus cv Excel and a glufosinate-resistant genotype (HCN27) derived by transformation of cv Excel with the phosphinothricin-N-acetyltransferase (pat) gene.
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17329002 Malley LA, Everds NE, Reynolds J, Mann PC, Lamb I, Rood T, Schmidt J, Layton RJ, Prochaska LM, Hinds M, Locke M, Chui CF, Claussen F, Mattsson JL, Delaney B: Subchronic feeding study of DAS-59122-7 maize grain in Sprague-Dawley rats. Food Chem Toxicol. 2007 Jul;45(7):1277-92. Epub 2007 Jan 25.

59122 is a transgenic maize line containing event DAS-59122-7 that expresses the corn rootworm (CRW) specific pesticidal Cry34Ab1 and Cry35Ab1 proteins from Bacillus thuringiensis (Bt) Berliner strain PS149B1 and the phosphinothricin-N-acetyltransferase (PAT) protein from Streptomyces viridochromogenes for tolerance to the herbicidal ingredient glufosinate-ammonium.
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16547651 Tan S, Evans R, Singh B: Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops. Amino Acids. 2006 Mar;30(2):195-204. Epub 2006 Mar 20.

Similarly, bar and pat genes isolated from Streptomyces hygroscopicus and S. viridochromogenes, respectively, have been inserted into plants to encode phosphinothricin N-acetyltransferase to detoxify glufosinate.
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17097206 MacKenzie SA, Lamb I, Schmidt J, Deege L, Morrisey MJ, Harper M, Layton RJ, Prochaska LM, Sanders C, Locke M, Mattsson JL, Fuentes A, Delaney B: Thirteen week feeding study with transgenic maize grain containing event DAS-O15O7-1 in Sprague-Dawley rats. Food Chem Toxicol. 2007 Apr;45(4):551-62. Epub 2006 Oct 4.

Maize line 1507, containing event DAS-O15O7-1 (1507), is a genetically modified (GM) maize plant that expresses the cry1F gene from Bacillus thuringiensis (Bt) sbsp. aizawai and the phosphinothricin-N-acetyltransferase (pat) gene from Streptomyces viridochromogenes throughout the plant including in the grain expression of the Cry1F protein confers in planta resistance to the European corn borer (ECB; Ostrinia nubilalis Hubner: Crambidae) and other lepidopteran pests.
Expression of the PAT protein confers tolerance to the herbicidal active ingredient glufosinate-ammonium.
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12232195 Droge-Laser W, Siemeling U, Puhler A, Broer I: The Metabolites of the Herbicide L-Phosphinothricin (Glufosinate) (Identification, Stability, and Mobility in Transgenic, Herbicide-Resistant, and Untransformed Plants). Plant Physiol. 1994 May;105(1):159-166.

In transgenic, Pt-resistant plants expressing the Pt-N-acetyltransferase gene (pat), L-Pt was acetylated, resulting in two forms of N-acetyl-Pt (ac-Pt).
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16535427 Franco AR, Lopez-Siles FJ, Cardenas J: Resistance to Phosphinothricin (Glufosinate) and Its Utilization as a Nitrogen Source by Chlamydomonas reinhardtii. Appl Environ Microbiol. 1996 Oct;62(10):3834-3839.

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