Protein Information

Name protoporphyrinogen oxidase
Synonyms Mutant protoporphyrinogen oxidase; VP; PPO; PPOX; Protoporphyrinogen oxidase; V290M; Protoporphyrinogen oxidases

Compound Information

Name oxadiargyl
CAS

Reference List

PubMed Abstract RScore(About this table)
16406601 Ma J, Wang S, Wang P, Ma L, Chen X, Xu R: Toxicity assessment of 40 herbicides to the green alga Raphidocelis subcapitata. Ecotoxicol Environ Saf. 2006 Mar;63(3):456-62.

The EC50 of the protoporphyrinogen oxidase inhibitor oxadiargyl, which was the parameter least sensitive to the herbicides tested in this study, was 42.5 mgL (-1).
32(0,1,1,2) Details
11368593 Dayan FE, Meazza G, Bettarini F, Signorini E, Piccardi P, Romagni JG, Duke SO: Synthesis, herbicidal activity, and mode of action of IR 5790. J Agric Food Chem. 2001 May;49(5):2302-7.

IR 5790, an arylthiadiazolone herbicide structurally related to oxadiargyl and oxadiazon, was synthesized.
The phenotypic responses of susceptible plants, such as interruption of growth and light-dependent development of necrotic areas on the foliage, are consistent with those observed with protoporphyrinogen oxidase-inhibiting herbicides.
2(0,0,0,2) Details
19954223 Jiang LL, Tan Y, Zhu XL, Wang ZF, Zuo Y, Chen Q, Xi Z, Yang GF: Design, synthesis, and 3D-QSAR analysis of novel 1,3,4-oxadiazol-2 (3H)-ones as protoporphyrinogen oxidase inhibitors. J Agric Food Chem. 2010 Mar 10;58(5):2643-51.

As a continuation of research work on the development of new PPO inhibitors, some benzothiazole analogues of oxadiargyl, an important PPO-inhibiting commercial herbicide, were designed and synthesized by ring-closing of the substituents at the C-4 and C-5 positions.
2(0,0,0,2) Details