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Richert L, Price S, Chesne C, Maita K, Carmichael N: Comparison of the induction of hepatic peroxisome proliferation by the herbicide oxadiazon in vivo in rats, mice, and dogs and in vitro in rat and human hepatocytes. Toxicol Appl Pharmacol. 1996 Nov;141(1):35-43.
When added in vitro to cultured rat hepatocytes at concentrations ranging from 2.5 to 10 x 10 (-5) M, oxadiazon induced a dose-dependent increase in the activities of palmitoyl CoA oxidase and acetyl carnitine transferase. |
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