| Name | isocitrate dehydrogenase |
|---|---|
| Synonyms | ICD M; IDH; IDP; NADP(+) specific ICDH; Oxalosuccinate decarboxylase; IDH 2; IDH2; IDHM… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15852400 | Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE: Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol. 2005 May;57(5):695-703. Significant (p < 0.01) decreases occurred in the activities of the pyruvate dehydrogenase complex (-41%), isocitrate dehydrogenase (-27%), and the alpha-ketoglutarate dehydrogenase complex (-57%). |
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| 18683263 | Lee EG, Yoon SH, Das A, Lee SH, Li C, Kim JY, Choi MS, Oh DK, Kim SW: Directing vanillin production from by increased consumption in recombinant Escherichia coli. Biotechnol Bioeng. 2009 Jan 1;102(1):200-8. The icdA gene encoding isocitrate dehydrogenase of TCA cycle was deleted to make the vanillin producing E. coli utilize bypass which enables more efficient conversion of to in comparison with TCA cycle. |
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| 16495757 | Sudharsan PT, Mythili Y, Selvakumar E, Varalakshmi P: Lupeol and its ester exhibit protective role against cyclophosphamide-induced cardiac mitochondrial toxicity. J Cardiovasc Pharmacol. 2006 Feb;47(2):205-10. A decrease in the activities of TCA cycle enzymes such as succinate dehydrogenase, malate dehydrogenase, and isocitrate dehydrogenase were noted in CP-treated rats. |
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| 19820141 | Becker J, Klopprogge C, Schroder H, Wittmann C: Metabolic engineering of the tricarboxylic acid cycle for improved production by Corynebacterium glutamicum. Appl Environ Microbiol. 2009 Dec;75(24):7866-9. Epub 2009 Oct 9. The 70% decreased activity of isocitrate dehydrogenase, achieved by start codon exchange, resulted in a > 40% improved production. |
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| 16194279 | Banerjee S, Nandyala A, Podili R, Katoch VM, Hasnain SE: Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation. BMC Biochem. 2005 Sep 29;6:20. BACKGROUND: M.tb icd-1 and M.tb icd-2, have been identified in the Mycobacterium tuberculosis genome as probable isocitrate dehydrogenase (ICD) genes. |
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| 12138751 | Il'chenko AP, Cherniavskaia OG, Shishkanova NV, Finogenova TV: [Metabolism of Yarrowia lipolytica grown on under conditions promoting the production of alpha-ketoglutaric and citric acids: a comparative study of the central metabolism enzymes]. Mikrobiologiia. 2002 May-Jun;71(3):316-22. A comparative study of the enzymes of the tricarboxylic acid (TCA) and cycles in the mutant Yarrowia lipolytica strain N1 capable of producing alpha-ketoglutaric acid (KGA) and showed that almost all enzymes of the TCA cycle are more active under conditions promoting the production of KGA. The activities of malate dehydrogenase, aconitase, -dependent isocitrate dehydrogenase, and fumarase were higher in cells producing KGA than in cells producing |
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| 17349985 | Arulkumaran S, Ramprasath VR, Shanthi P, Sachdanandam P: Alteration of DMBA-induced oxidative stress by additive action of a modified indigenous preparation--Kalpaamruthaa. Chem Biol Interact. 2007 Apr 25;167(2):99-106. Epub 2007 Feb 4. DMBA-treated rats also showed decline in the activities of mitochondrial enzymes such as succinate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase. |
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| 16085348 | Mythili Y, Sudharsan PT, Varalakshmi P: ameliorates cyclophosphamide induced cardiac mitochondrial injury. Toxicology. 2005 Nov 5;215(1-2):108-14. Epub 2005 Aug 8. A decrease in the activities of TCA cycle enzymes such as succinate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase was noted in CP treated rats. |
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| 17020548 | Denayer S, Matthijs S, Cornelis P: Resistance to in Pseudomonas fluorescens ATCC 17400 caused by mutations in TCA cycle enzymes. FEMS Microbiol Lett. 2006 Nov;264(1):59-64. One mutant had an insertion in the idh gene coding for the tricarboxylic acid enzyme isocitrate dehydrogenase. |
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| 16906525 | Mailloux RJ, Hamel R, Appanna VD: Aluminum toxicity elicits a dysfunctional TCA cycle and accumulation in hepatocytes. J Biochem Mol Toxicol. 2006;20(4):198-208. BN-PAGE, SDS-PAGE, and Western blot analyses revealed a marked decrease in activity and expression of succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (KGDH), isocitrate dehydrogenase-NAD+ (IDH), fumarase (FUM), aconitase (ACN), and cytochrome c oxidase (Cyt C Ox). 13C-NMR and HPLC studies further confirmed the disparate metabolism operative in control and Al-stressed cells and provided evidence for the accumulation of in the latter cultures. |
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| 16275767 | Akimoto H, Kinumi T, Ohmiya Y: Circadian rhythm of a TCA cycle enzyme is apparently regulated at the translational level in the dinoflagellate Lingulodinium polyedrum. J Biol Rhythms. 2005 Dec;20(6):479-89. The -dependent isocitrate dehydrogenase (NADPICDH) in the TCA cycle exhibited circadian changes of protein abundance and enzyme activity under all conditions, whereas its mRNA level remained constant throughout the cycle. |
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| 14526533 | Pirog TP, Kuz'minskaia IuV: [Central metabolism in Acinetobacter sp. grown on . Mikrobiologiia. 2003 Jul-Aug;72(4):459-65. This was evident from the high activity of isocitrate dehydrogenase and dehydrogenase and the low activity of dehydrogenase. |
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| 12655459 | Peng L, Shimizu K: Global metabolic regulation analysis for Escherichia coli K12 based on protein expression by 2-dimensional electrophoresis and enzyme activity measurement. Appl Microbiol Biotechnol. 2003 Apr;61(2):163-78. Epub 2003 Jan 9. Protein abundance obtained by 2DE correlated well with enzyme activity, with a few exceptions (e.g., isocitrate dehydrogenase), during aerobic growth on |
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| 20353438 | Lemire J, Mailloux R, Auger C, Whalen D, Appanna VD: Pseudomonas fluorescens orchestrates a fine metabolic-balancing act to counter aluminium toxicity. Environ Microbiol. 2010 Mar 25. To counter the Fe conundrum induced by Al toxicity, Pseudomonas fluorescens utilizes lyase and isocitrate dehydrogenase- dependent to metabolize when confronted with an ineffective aconitase provoked by Al stress. |
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| 12841626 | Malarkodi KP, Balachandar AV, Varalakshmi P: The influence of on adriamycin induced nephrotoxicity in rats. Mol Cell Biochem. 2003 May;247(1-2):15-22. Decreased activities of the TCA cycle enzymes isocitrate dehydrogenase, succinate dehydrogenase and malate dehydrogenase, suggest a loss in mitochondrial function and integrity. |
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| 15574927 | Wittmann C, Kiefer P, Zelder O: Metabolic fluxes in Corynebacterium glutamicum during production with as carbon source. Appl Environ Microbiol. 2004 Dec;70(12):7277-87. Isocitrate dehydrogenase therefore significantly contributed to the total supply of 190%. |
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| 20304625 | Bayley JP, Devilee P: Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Curr Opin Genet Dev. 2010 Mar 19. Another mitochondrial and TCA cycle-related protein, isocitrate dehydrogenase 2 is, together with IDH1, frequently mutated in the brain tumour glioblastoma. |
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| 20199583 | Kamaraj S, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T: attenuates mitochondrial dysfunction during benzo (a) pyrene-induced lung carcinogenesis in mice. Fundam Clin Pharmacol. 2010 Feb 22. B (a) P (50 mg/kg body weight)-induced mitochondrial abnormalities was evident from alterations in mitochondrial lipid peroxides, antioxidant status (superoxide dismutase, catalase, peroxidase, glutathione reductase, glutathione-S-transferase, and major tricarboxylic acid (TCA) cycle enzyme activities (isocitrate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase), electron transport chain (ETC) complexes activities and levels. |
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| 20222442 | Zhang D, Liu L, Du G, Chen J: [Physiological function of alpha-ketoglutarate dehydrogenase complex in Torulopsis glabrata]. Wei Sheng Wu Xue Bao. 2009 Dec 4;49(12):1584-9. But the specific activities of pyruvate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase increased by 58.1%, 33.3% and 32.5%, respectively; (c) the intracellular concentration of was reduced by 49.9%, while the intracellular concentration of and alpha-ketoglutarate was higher 172.7%, 66.1% and 41.1% than the corresponding values of the control; (d) The content of -family amino acid was 29.3% lower while the level of -family amino acid and -family amino acid were 34.7% and 26.8% higher than that of control. |
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| 16786185 | Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T: Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Mol Cell Biochem. 2007 Jan;294(1-2):55-63. Epub 2006 Jun 20. Adriamycin (2.5 mg/kg body wt., i.p.) induced mitochondrial damage in rats was assessed in terms of decreased activities (p <0.05) of cardiac marker enzymes (lactate dehydrogenase, phosphokinase, amino transferases), TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate dehydrogenase, respiratory marker enzymes (NADH-dehydrogenase, cytochrome-C-oxidase), mitochondrial antioxidant enzymes (GPx, GSH, SOD,CAT) and increased (p <0.05) level of lipid peroxidation. |
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| 12668482 | Cortassa S, Aon MA, Marban E, Winslow RL, O'Rourke B: An integrated model of cardiac mitochondrial energy metabolism and dynamics. Biophys J. 2003 Apr;84(4):2734-55. In addition, mitochondrial matrix Ca (2+), determined by Ca (2+) uniporter and Na (+)/Ca (2+) exchanger activities, regulates activity of the TCA cycle enzymes isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase. |
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| 15048835 | Das R, Gerstein M: A method using active-site sequence conservation to find functional shifts in protein families: application to the enzymes of central metabolism, leading to the identification of an anomalous isocitrate dehydrogenase in pathogens. Proteins. 2004 May 1;55(2):455-63. |
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| 18569708 | Rajendran P, Ekambaram G, Sakthisekaran D: Effect of mangiferin on benzo (a) pyrene induced lung carcinogenesis in experimental Swiss albino mice. Nat Prod Res. 2008 May 20;22(8):672-80. Decreased activities of electron transport chain complexes and TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), in lung cancer bearing animals were observed. |
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| 20136350 | Muralikrishnan G, Amanullah S, Basha MI, Dinda AK, Shakeel F: Modulating effect of Withania somnifera on TCA cycle enzymes and electron transport chain in azoxymethane-induced colon cancer in mice. Immunopharmacol Immunotoxicol. 2010 Feb 5. After the experimental period, the animals were killed and analyzed for TCA cycle key enzymes, such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and alpha-keto dehydrogenase (alpha-KGDH). |
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| 16233178 | Kirimura K, Yoda M, Kumatani M, Ishii Y, Kino K, Usami S: Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial -specific isocitrate dehydrogenase. J Biosci Bioeng. 2002;93(2):136-44. |
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| 12119542 | Madej M, Lundh T, Lindberg JE: Activity of enzymes involved in energy production in the small intestine during suckling-weaning transition of pigs. Biol Neonate. 2002;82(1):53-60. The activity of citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, dehydrogenase, alanine aminotransferase and aspartate aminotransferase was determined in the small intestine epithelium of piglets during suckling-weaning transition. |
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| 14568142 | Wang ZX, Bramer C, Steinbuchel A: Two phenotypically compensating isocitrate dehydrogenases in Ralstonia eutropha. FEMS Microbiol Lett. 2003 Oct 10;227(1):9-16. The tricarboxylic acid (TCA) cycle enzyme isocitrate dehydrogenase (IDH) and the bypass enzyme lyase are involved in catabolism of and play a key role in controlling the metabolic flux between the TCA cycle and the shunt. |
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| 20035036 | Sienkiewicz-Porzucek A, Sulpice R, Osorio S, Krahnert I, Leisse A, Urbanczyk-Wochniak E, Hodges M, Fernie AR, Nunes-Nesi A: Mild Reductions in Mitochondrial NAD-Dependent Isocitrate Dehydrogenase Activity Result in Altered Assimilation and Pigmentation But Do Not Impact Growth. Mol Plant. 2010 Jan;3(1):156-73. Epub 2009 Dec 24. Transgenic tomato (Solanum lycopersicum) plants were generated expressing a fragment of the mitochondrial NAD-dependent isocitrate dehydrogenase gene (SlIDH1) in the antisense orientation. |
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| 12694190 | Wrenger C, Muller S: Isocitrate dehydrogenase of Plasmodium falciparum. Eur J Biochem. 2003 Apr;270(8):1775-83. |
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| 16362493 | Jung IL, Kim SK, Kim IG: The RpoS-mediated regulation of isocitrate dehydrogenase gene expression in Escherichia coli. Curr Microbiol. 2006 Jan;52(1):21-6. Epub 2005 Dec 13. |
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| 18825970 | Mysiakina IS, Funtikova NS: [Activity of NAD-dependent isocitrate dehydrogenase, lyase, and malate dehydrogenase in Mucor circinelloides var. lusitanicus INMI under different modes of supply]. Mikrobiologiia. 2008 Jul-Aug;77(4):453-9. |
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| 19385702 | Vinekar R, Ghosh I: Determination of phosphorylation sites for -specific isocitrate dehydrogenase from mycobacterium tuberculosis. J Biomol Struct Dyn. 2009 Jun;26(6):741-54. |
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| 17668068 | Mailloux RJ, Beriault R, Lemire J, Singh R, Chenier DR, Hamel RD, Appanna VD: The tricarboxylic acid cycle, an ancient metabolic network with a novel twist. PLoS One. 2007 Aug 1;2(1):e690. Thus, the increased production of KG mediated by -dependent isocitrate dehydrogenase -ICDH) and its decreased utilization via the TCA cycle confer a unique strategy to modulate the cellular redox environment. |
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| 16232608 | Asano T, Kurose N, Hiraoka N, Kawakita S: Effect of NAD+-dependent isocitrate dehydrogenase gene (IDH1, IDH2) disruption of sake yeast on organic acid composition in sake mash. J Biosci Bioeng. 1999;88(3):258-63. |
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| 16269086 | Frick O, Wittmann C: Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb Cell Fact. 2005 Nov 3;4:30. During oxidative growth mainly the NAD specific isoforms of dehydrogenase and isocitrate dehydrogenase catalyze the corresponding reactions in S. cerevisiae, whereas supply under fermentative conditions involves significant contribution of sources other than the PPP such as e. g. |
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| 18094529 | Choi YJ, Uhm SJ, Song SJ, Song H, Park JK, Kim T, Park C, Kim JH: Cytochrome c upregulation during capacitation and spontaneous acrosome reaction determines the fate of pig sperm cells: linking proteome analysis. J Reprod Dev. 2008 Feb;54(1):68-83. Epub 2007 Dec 18. After induction of capacitation in vitro, the well-established markers of the capacitation (lactadherin P47, acrosomal protein SP-10 precursor, prohibitin, proteasomes, DJ-1 protein and arylsulfatase-A) and TCA cycle proteins (isocitrate dehydrogenase, malate dehydrogenase and pyruvate dehydrogenase) were identified. |
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| 19002891 | Zhang F, Sun X, Yi X, Zhang Y: Metabolic characteristics of recombinant Chinese hamster ovary cells expressing glutamine synthetase in presence and absence of Cytotechnology. 2006 May;51(1):21-8. Epub 2006 Aug 5. On the other hand, intracellular and the activities of its downstream isocitrate dehydrogenase in the TCA cycle increased also. |
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| 16413626 | Mohankumar K, Ramasamy P: Activities of membrane bound phosphatases, transaminases and mitochondrial enzymes in white spot syndrome virus infected tissues of Fenneropenaeus indicus. Virus Res. 2006 Jun;118(1-2):130-5. Epub 2006 Jan 18. The activities of membrane bound phosphatases (Na (+) K (+) ATPase, Ca (2+) ATPase, Mg (2+) ATPase and Total ATPase), transaminases transaminase (ALT) and transaminase (AST)) and mitochondrial enzymes (isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), alpha-ketoglutarate dehydrogenase (KGDH), NADH dehydrogenase, cytochrome C oxidase) in WSSV-infected tissues (hemolymph, hepatopancreas, gills and muscle) of Fenneropenaeus indicus were determined at intervals after WSSV infection (0, 24, 48, 72 and after 72 h (moribund)). |
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| 16857877 | Walsh PJ, Kajimura M, Mommsen TP, Wood CM: Metabolic organization and effects of feeding on enzyme activities of the dogfish shark (Squalus acanthias) rectal gland. J Exp Biol. 2006 Aug;209(Pt 15):2929-38. Several enzymes showed a large increase in activity post-feeding, including dehydrogenase in rectal gland and liver, and in rectal gland, isocitrate dehydrogenase, citrate synthase, lactate dehydrogenase, amino transferase, amino transferase, glutamine synthetase and Na (+)/K (+) ATPase. |
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| 16839657 | Chan M, Tan DS, Wong SH, Sim TS: A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization. Biochimie. 2006 Oct;88(10):1367-75. Epub 2006 Jun 22. These eukaryotic cells serve as an in vitro living system for studying the cellular destinations of four mitochondrial-targeted TCA cycle proteins (citrate synthase, CS; isocitrate dehydrogenase, ICDH; branched chain alpha-keto-acid dehydrogenase E1alpha subunit, BCKDH; succinate dehydrogenase flavoprotein-subunit, SDH), two nuclear-targeted proteins (histone deacetylase, HDAC; RNA polymerase, RPOL), two apicoplast-targeted proteins kinase 2, PK2; dehydrogenase, GDH), and two cytoplasmic resident proteins (malate dehydrogenase, MDH; glycerol kinase, GK). |
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| 18337490 | Morgan MJ, Lehmann M, Schwarzlander M, Baxter CJ, Sienkiewicz-Porzucek A, Williams TC, Schauer N, Fernie AR, Fricker MD, Ratcliffe RG, Sweetlove LJ, Finkemeier I: Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis. Plant Physiol. 2008 May;147(1):101-14. Epub 2008 Mar 12. However, there were specific inhibitions of tricarboxylic acid (TCA) cycle enzymes (aconitase and isocitrate dehydrogenase) and an inhibition of TCA cycle flux in isolated mitochondria. |
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| 12226865 | Weber J, Hoffmann F, Rinas U: Metabolic adaptation of Escherichia coli during temperature-induced recombinant protein production: 2. Biotechnol Bioeng. 2002 Nov 5;80(3):320-30. Upon temperature upshift, an excess of was produced in the TCA cycle by isocitrate dehydrogenase. |
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| 15881660 | Selvendiran K, Thirunavukkarasu C, Singh JP, Padmavathi R, Sakthisekaran D: Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-I and -metabolizing enzymes in benzo (a) pyrene induced lung carcinogenesis in Swiss albino mice. Mol Cell Biochem. 2005 Mar;271(1-2):101-6. Lung cancer bearing mice showed a significant decrease in the activities of mitochondrial enzymes-isocitrate dehydrogenase (ICDH), -ketoglutarate dehydrogenase (KDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and significantly increased -Cytochorome reductase -C reductase), cytochrome P450 (cyt-p450) and cytochrome b5 (cyt-b5). |
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| 18951770 | Bhatt DK, Bano M: Modulation of tricarboxylic acid cycle dehydrogenases during hepatocarcinogenesis induced by hexachlorocyclohexane in mice. Exp Toxicol Pathol. 2009 Jul;61(4):325-32. Epub 2008 Oct 31. The activity of TCA cycle enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) have been studied. |
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| 14748694 | Cetica P, Pintos L, Dalvit G, Beconi M: Involvement of enzymes of amino acid metabolism and tricarboxylic acid cycle in bovine oocyte maturation in vitro. Reproduction. 2003 Dec;126(6):753-63. ALT, AST, -dependent isocitrate dehydrogenase -IDH) and MDH enzymatic units remained constant in cumulus cells and oocytes during IVM. |
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| 17574827 | Buddhan S, Sivakumar R, Dhandapani N, Ganesan B, Anandan R: Protective effect of dietary supplementation on mitochondrial function in liver of aged rats. Prostaglandins Leukot Essent Fatty Acids. 2007 Jun;76(6):349-55. Epub 2007 Jun 15. The dietary supplementation of 2% significantly minimized aging associated alterations in mitochondrial energy status by maintaining the activities of TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase) and respiratory marker enzymes (NADH dehydrogenase and cytochrome-c-oxidase) at higher level in the liver mitochondria of aged rats compared with unsupplemented controls. |
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| 18001705 | Veena CK, Josephine A, Preetha SP, Rajesh NG, Varalakshmi P: Mitochondrial dysfunction in an animal model of hyperoxaluria: a prophylactic approach with fucoidan. Eur J Pharmacol. 2008 Jan 28;579(1-3):330-6. Epub 2007 Oct 16. The tricarboxylic acid (TCA) cycle enzymes like succinate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase and respiratory complex enzyme activities were assessed to evaluate mitochondrial function. |
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| 14604472 | Arathi G, Sachdanandam P: Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. J Pharm Pharmacol. 2003 Sep;55(9):1283-90. The activities of mitochondrial enzymes isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH-dehydrogenase and cytochrome C oxidase were significantly lowered in mammary carcinoma-bearing rats when compared with control rats. |
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| 16143346 | Senthilnathan P, Padmavathi R, Magesh V, Sakthisekaran D: Modulation of TCA cycle enzymes and electron transport chain systems in experimental lung cancer. Life Sci. 2006 Jan 25;78(9):1010-4. Epub 2005 Sep 6. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in lung cancer bearing animals were observed. |
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| 15919137 | Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C: Efficacy of levo and in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005 Oct;24(5):794-800. METHODS: In the present study we have evaluated the efficacy of a mitochondrial metabolite and a potent antioxidant on the activities of the tri carboxylic acid (TCA) cycle enzymes like succinate dehydrogenase, malate dehydrogenase, alpha-ketoglutarate dehydrogenase, Isocitrate dehydrogenase and electron transport complex I-IV in young and aged heart mitochondria. |
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| 19053364 | Schiavon M, Ertani A, Nardi S: Effects of an alfalfa protein hydrolysate on the gene expression and activity of enzymes of the tricarboxylic acid (TCA) cycle and nitrogen metabolism in Zea mays L. J Agric Food Chem. 2008 Dec 24;56(24):11800-8. The activity of a number of enzymes involved in carbon (C) metabolism (malate dehydrogenase, MDH; isocitrate dehydrogenase, IDH; citrate synthase, CS) and N reduction and assimilation reductase, NR; reductase, NiR; glutamine synthetase, GS; synthase, GOGAT; aspartate aminotransferase, AspAT) was significantly induced by EM supply to plants, and the transcription pattern of MDH, IDH, CS, and NR strongly correlated with data of enzyme activity. |
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| 12631716 | McCammon MT, Epstein CB, Przybyla-Zawislak B, McAlister-Henn L, Butow RA: Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell. 2003 Mar;14(3):958-72. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. |
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