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Jucker BM, Yang D, Casey WM, Olzinski AR, Williams C, Lenhard SC, Legos JJ, Hawk CT, Sarkar SK, Newsholme SJ: Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1256-64. Epub 2007 Aug 28.
In separate experiments where mitochondrial coupling was assessed in vivo (day 7), (31) P-MRS was used to measure hindlimb ATP synthesis and (13) C-MRS was used to measure the hindlimb tricarboxylic acid cycle flux (V (tca)). |
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