| Name | CD86 |
|---|---|
| Synonyms | Activation B7 2 antigen; B lymphocyte activation antigen B7 2; B7 2; B70; BU63; CD28 antigen ligand 2; CD28LG2; CD86… |
| Name | benzalkonium chloride |
|---|---|
| CAS | quaternary ammonium compounds, alkylbenzyldimethyl, chlorides |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19338585 | An S, Kim S, Huh Y, Lee TR, Kim HK, Park KL, Eun HC: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals. Contact Dermatitis. 2009 Apr;60(4):185-92. METHODS: We investigated the expression of CD54, CD86, CD83, CD80, and CD40 after a 1-day exposure to sensitizers (1-chloro-2,4-dinitrobenzene; 2,4-dinitrofluorobenzene; 5-chloro-2-methyl-4-isothiazolin-3-one; hexyl hexahydrate; dichromate; 2-mercaptobenzothiazole; and ammonium tetrachloroplatinate) and non-sensitizers benzalkonium chloride, lactic acid, and |
8(0,0,1,3) | Details |
| 19033392 | Ade N, Leon F, Pallardy M, Peiffer JL, Kerdine-Romer S, Tissier MH, Bonnet PA, Fabre I, Ourlin JC: HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. Toxicol Sci. 2009 Feb;107(2):451-60. Epub 2008 Nov 25. A significant inhibition of the expression of hmox1 and nqo1 mRNAs and CD86 expression was found in 1-chloro 2,4-dinitrobenzene-treated THP-1 cells preincubated with N-acetyl a precursor. CD34-derived dendritic cells (CD34-DC) and the THP-1 myeloid cell line were treated by a panel of sensitizers (Ni, 1-chloro 2,4-dinitrobenzene, 7-hydroxycitronellal, 1,4- alpha-methyl- 2-4-tert-(butylbenzyl) or Lilial, and 1,4-phenylenediamine), irritants benzalkonium chloride), and a nonsensitizer molecule (chlorobenzene). |
1(0,0,0,1) | Details |
| 12603851 | Aiba S, Manome H, Nakagawa S, Mollah ZU, Mizuashi M, Ohtani T, Yoshino Y, Tagami H: p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol. 2003 Mar;120(3):390-9. In contrast, primary irritants, e.g., benzalkonium chloride, or did not activate these signal transduction pathways. By using specific inhibitors for extracellular signal-regulated kinases and p38 pathways, PD98059 and SB203580, respectively, we demonstrated that the augmentation of CD86, HLA-DR, and CD83, and the production of interleukin-8 along with its increased mRNA expression by monocyte-derived dendritic cells stimulated with 2,4-dinitrochlorobenzene, and the augmentation of CD83 and the interleukin-12 p40 production by monocyte-derived dendritic cells stimulated with NiCl2, were suppressed by SB203580, whereas PD98059 suppressed the production of interleukin-1beta and tumor necrosis factor-alpha, together with their increased mRNA expression by monocyte-derived dendritic cells treated with NiCl2. |
1(0,0,0,1) | Details |
| 11238627 | Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C: A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol. 2001 Mar 15;166(6):3837-45. DC maturation induced by the contact sensitizers 2,4-dinitrofluorobenzene and NiSO (4), as seen by the up-regulation of CD80, CD86, and CD83, was also coupled to the phosphorylation of p38 MAPK, and was inhibited by SB203580. The irritants SDS and benzalkonium chloride that do not induce DC maturation did not trigger p38 MAPK phosphorylation. |
1(0,0,0,1) | Details |
| 15885735 | Hulette BC, Ryan CA, Gildea LA, Gerberick GF: Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen. Toxicol Appl Pharmacol. 2005 Dec 1;209(2):159-66. For comparison, DC were treated with the irritants (SDS), (BA), and benzalkonium chloride (BZC) at concentrations resulting in comparable levels of cytotoxicity. |
6(0,0,0,6) | Details |
| 10495778 | Gerberick GF, Cruse LW, Miller CM, Ridder GM: Selective modulation of B-cell activation markers CD86 and I-Ak on murine draining lymph node cells following allergen or irritant treatment. Toxicol Appl Pharmacol. 1999 Sep 1;159(2):142-51. Mice were treated on the ears for 3 consecutive days with concentrations of allergens (1-chloro-2,4-dinitrobenzene, alpha-hexylcinnamaldehyde, 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one, and trinitrochlorobenzene), or irritants (benzalkonium chloride and which caused an increase in the number of DLN cells. |
4(0,0,0,4) | Details |
| 9394834 | Aiba S, Terunuma A, Manome H, Tagami H: Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol. 1997 Nov;27(11):3031-8. After we confirmed that monocyte-derived DC showed at least phenotypic characteristics and a response to TNF-alpha similar to LC, we added various chemicals, i.e., dinitrochlorobenzene (DNCB), trinitrochlorobenzene (TNCB), NiCl2, ZnCl2, (SDS), or benzalkonium chloride (BC), to a culture of purified monocyte-derived CD1a+ DC. The increase in the expression of CD86 induced by NiCl2 or DNCB was most remarkable, being observed in DC from almost all the subjects we examined. |
3(0,0,0,3) | Details |
| 15372140 | Straube F, Grenet O, Bruegger P, Ulrich P: Contact allergens and irritants show discrete differences in the activation of human monocyte-derived dendritic cells: consequences for in vitro detection of contact allergens. Arch Toxicol. 2005 Jan;79(1):37-46. Epub 2004 Sep 15. MoDC were generated by 6 days of culture in the presence of IL-4 and GM-CSF and were then cultured for 24 or 48 h in medium with lipopolysaccharide (LPS), contact allergens [picrylsulphonic acid (TNBS), 1-chloro-2,4-dinitrobenzene (DNCB)] or irritants (SDS), benzalkonium chloride (BAC)] that were free of detectable endotoxin contamination. The induction of CD86 and HLA-DR expression was quantified by flow cytometry as markers for MoDC activation. |
3(0,0,0,3) | Details |
| 16314067 | Hirota M, Moro O: MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicol In Vitro. 2006 Aug;20(5):736-42. Epub 2005 Nov 28. Secretion of MIP-1 beta from THP-1 was detected after 24-h treatment with sensitizers such as DNCB, Ni, 2-mercaptobenzothiazole (2-MBT) and (Co), while pPD and non-sensitizers such as (SDS) and benzalkonium chloride (BC) had no effect. The use of both MIP-1 beta production and CD86 expression as criteria reduced the number of false-negatives, and the results were in good agreement with those of in vivo assays. |
1(0,0,0,1) | Details |