Protein Information

Name 6 phosphogluconate dehydrogenase
Synonyms 6PGD; PGD; PGDH; Phosphogluconate dehydrogenase; Phosphogluconate dehydrogenases; 6 phospho D gluconate dehydrogenase; GNTZII; 6 phosphogluconic dehydrogenase…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
19603213 Wu L, Li Z, Ye Q: Enhanced D-ribose biosynthesis in batch culture of a transketolase-deficient Bacillus subtilis strain by citrate. J Ind Microbiol Biotechnol. 2009 Oct;36(10):1289-96. Epub 2009 Jul 15.


Addition of citrate reduced the activities of pyruvate kinase and phosphofructokinase, while it increased those of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.
1(0,0,0,1) Details
15691747 Mashego MR, Jansen ML, Vinke JL, van Gulik WM, Heijnen JJ: Changes in the metabolome of Saccharomyces cerevisiae associated with evolution in aerobic glucose-limited chemostats. FEMS Yeast Res. 2005 Feb;5(4-5):419-30.


Exceptions to this were hexokinase, phosphofructokinase, pyruvate kinase and 6-phosphogluconate dehydrogenase of which the activities remained unchanged.
1(0,0,0,1) Details
16233247 Lim SJ, Jung YM, Shin HD, Lee YH: Amplification of the NADPH-related genes zwf and gnd for the oddball biosynthesis of PHB in an E. coli transformant harboring a cloned phbCAB operon. J Biosci Bioeng. 2002;93(6):543-9.


NADPH, a major reducing power in microorganisms, is mostly generated from the pentose phosphate (PP) pathway by glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) expressed by the zwf and gnd genes, respectively.
1(0,0,0,1) Details
17531451 Panneerselvam R, Abdul Jaleel C, Somasundaram R, Sridharan R, Gomathinayagam M: Carbohydrate metabolism in Dioscorea esculenta (Lour.) Burk. tubers and Curcuma longa L. rhizomes during two phases of dormancy. Colloids Surf B Biointerfaces. 2007 Sep 1;59(1):59-66. Epub 2007 Apr 21.


The key enzymes of glycolysis, TCA cycle and PPP, viz. aldolase, succinic dehydrogenase, malic dehydrogenase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were increased even before the visible appearance of sprouting and their activities were at their maximum during sprouting.
1(0,0,0,1) Details