Protein Information

Name phosphoglucose isomerase
Synonyms AMF; NLK; PGI; GNPI; GPI; Autocrine motility factor; GPI protein; Glucose 6 phosphate isomerase…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
17316901 Morland C, Henjum S, Iversen EG, Skrede KK, Hassel B: Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochem Int. 2007 Apr;50(5):703-9. Epub 2007 Jan 20.


White structures had an uptake of [(3) H] 2-deoxyglucose in vivo and activities of hexokinase, glucose-6-phosphate isomerase, and lactate dehydrogenase that were 40-50% of values in parietal cortex.
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15574927 Wittmann C, Kiefer P, Zelder O: Metabolic fluxes in Corynebacterium glutamicum during lysine production with sucrose as carbon source. Appl Environ Microbiol. 2004 Dec;70(12):7277-87.


Glucose-6-phosphate isomerase operated in the gluconeogenetic direction from fructose-6-phosphate to glucose-6-phosphate and supplied additional carbon (7.2%) from the fructose part of the substrate toward the PPP.
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15690349 Wittmann C, Hans M, van Winden WA, Ras C, Heijnen JJ: Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae. Biotechnol Bioeng. 2005 Mar 30;89(7):839-47.


Minor differences resulted for phosphoglucose isomerase and enolase.
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18956755 Huang J, Xu Q, Wen T, Chen N: [Metabolic flux analysis of L-threonine biosynthesis strain under diverse dissolved oxygen conditions]. Wei Sheng Wu Xue Bao. 2008 Aug 4;48(8):1056-60.


CONCLUSION: Compared to the optimal metabolic flux with a carbon conversion rate of 88.23%, glucose-6-phosphate isomerase should be activated by genetic manipulation and fermentation control in order to elevate the HMP pathway flux, and flux towards aspartate amino acids family could be enhanced by increasing phosphoenolpyruvate carboxylase reaction rate.
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