Protein Information

Name vascular endothelial growth factor
Synonyms VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
20081247 Kubera M, Grygier B, Arteta B, Urbanska K, Basta-Kaim A, Budziszewska B, Leskiewicz M, Kolaczkowska E, Maes M, Szczepanik M, Majewska M, Lason W: Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice. Pharmacol Rep. 2009 Nov-Dec;61(6):1113-26.


To determine the effect of antidepressant drug pretreatment and tumor progress on some parameters of cell-mediated immunity (proliferative activity and cytokine production by splenocytes) and angiogenesis, vascular endothelial growth factor (VEGF) and metalloproteinase (MMP)-9 plasma levels were established.
2(0,0,0,2) Details
17724602 Yonei N, Kanazawa N, Ohtani T, Furukawa F, Yamamoto Y: Induction of PDGF-B in TCA-treated epidermal keratinocytes. . Arch Dermatol Res. 2007 Nov;299(9):433-40. Epub 2007 Aug 28.


In addition, expressions of PDGF-B, tumor growth factor (TGF)-alpha, TGF- beta1 and vascular endothelial growth factor, which are the growth factors reportedly secreted from keratinocytes during wound healing, were all detected in Pam212 cells after short-term treatment with TCA.
1(0,0,0,1) Details
15277511 Slomiany MG, Rosenzweig SA: IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2838-47.

9(0,0,0,9) Details