| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18565563 | Ramdhan DH, Kamijima M, Yamada N, Ito Y, Yanagiba Y, Nakamura D, Okamura A, Ichihara G, Aoyama T, Gonzalez FJ, Nakajima T: Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1. Toxicol Appl Pharmacol. 2008 Sep 15;231(3):300-7. Epub 2008 May 2. |
6(0,0,0,6) | Details |
| 12183104 | Forkert PG, Lash LH, Nadeau V, Tardif R, Simmonds A: Metabolism and toxicity of trichloroethylene in epididymis and testis. . Toxicol Appl Pharmacol. 2002 Aug 1;182(3):244-54. Cytochrome P450 2E1 (CYP2E1), an enzyme involved in TCE metabolism, was localized in the epididymal epithelium and testicular Leydig cells, and was found at higher levels in the former than the latter. |
3(0,0,0,3) | Details |
| 17267091 | Philip BK, Mumtaz MM, Latendresse JR, Mehendale HM: Impact of repeated exposure on toxicity of perchloroethylene in Swiss Webster mice. Toxicology. 2007 Mar 22;232(1-2):1-14. Epub 2006 Dec 22. Enzymes other than CYP2E1, involved in the metabolism of Perc may play a critical role in the metabolism of Perc upon subchronic exposure in SW mice. |
1(0,0,0,1) | Details |
| 12584157 | Forkert PG, Lash L, Tardif R, Tanphaichitr N, Vandevoort C, Moussa M: Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene. Drug Metab Dispos. 2003 Mar;31(3):306-11. CYP2E1, a P450 that metabolizes TCE, was localized in human and monkey epididymal epithelium and testicular Leydig cells. |
1(0,0,0,1) | Details |
| 15799452 | St-Pierre A, Krishnan K, Tardif R: Characterization of the metabolic interaction between trihalomethanes and chloroacetic acids using rat liver microsomes. J Toxicol Environ Health A. 2005 Feb 27;68(4):287-98. These results suggest that CYP2E1 is involved in the metabolism of THMs as well as in the metabolic interaction between THMs and TCA. |
1(0,0,0,1) | Details |
| 16882532 | Bronley-DeLancey A, McMillan DC, McMillan JM, Jollow DJ, Mohr LC, Hoel DG: Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. Environ Health Perspect. 2006 Aug;114(8):1237-42. Chloral hydrate (CH) is the major metabolite of TCE formed in the liver by cytochrome P450 2E1. |
1(0,0,0,1) | Details |