| Name | citrate synthase |
|---|---|
| Synonyms | CS; Citrate synthase; Citrate synthase mitochondrial; Citrate synthases; Citrate synthase mitochondrials |
| Name | TCA |
|---|---|
| CAS | 2,2,2-trichloroacetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12788763 | Krishnan HB, Kim WS, Sun-Hyung J, Kim KY, Jiang G: Citrate synthase mutants of Sinorhizobium fredii USDA257 form ineffective nodules with aberrant ultrastructure. Appl Environ Microbiol. 2003 Jun;69(6):3561-8. |
6(0,0,0,6) | Details |
| 12549038 | Liu Q, Yu L, Han XF, Fu Q, Zhang JX, Tang H, Zhao SY: [Cloning and tissue expression pattern analysis of the human citrate synthase cDNA]. Shi Yan Sheng Wu Xue Bao. 2000 Sep;33(3):207-14. |
5(0,0,0,5) | Details |
| 15720082 | Grzemski W, Akowski JP, Kahn ML: Probing the Sinorhizobium meliloti-alfalfa symbiosis using temperature-sensitive and impaired-function citrate synthase mutants. Mol Plant Microbe Interact. 2005 Feb;18(2):134-41. |
3(0,0,0,3) | Details |
| 20173036 | Murray SL, Hynes MJ: Metabolic and developmental effects resulting from deletion of the citA gene encoding citrate synthase in Aspergillus nidulans. Eukaryot Cell. 2010 Feb 19. |
3(0,0,0,3) | Details |
| 15098932 | Malthankar GV, White BK, Bhushan A, Daniels CK, Rodnick KJ, Lai JC: Differential lowering by treatment of activities of glycolytic and tricarboxylic acid (TCA) cycle enzymes investigated in neuroblastoma and astrocytoma cells is associated with -induced cell death. Neurochem Res. 2004 Apr;29(4):709-17. In parallel with the Mn-induced, dose-dependent decrease in cell survival, treatment of these cells with 0.01 to 4.0 mM MnCl2 for 48 h also induced dose-related decreases in their activities of hexokinase, kinase, lactate dehydrogenase, citrate synthase, and malate dehydrogenase. |
3(0,0,0,3) | Details |
| 16857877 | Walsh PJ, Kajimura M, Mommsen TP, Wood CM: Metabolic organization and effects of feeding on enzyme activities of the dogfish shark (Squalus acanthias) rectal gland. J Exp Biol. 2006 Aug;209(Pt 15):2929-38. Several enzymes showed a large increase in activity post-feeding, including dehydrogenase in rectal gland and liver, and in rectal gland, isocitrate dehydrogenase, citrate synthase, lactate dehydrogenase, amino transferase, amino transferase, glutamine synthetase and Na (+)/K (+) ATPase. |
2(0,0,0,2) | Details |
| 19887598 | Ritov VB, Menshikova EV, Azuma K, Wood RJ, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE: Deficiency of Electron Transport Chain in Human Skeletal Muscle Mitochondria in Type 2 Diabetes Mellitus and Obesity. Am J Physiol Endocrinol Metab. 2009 Nov 3. Study Design and Methods Frozen skeletal muscle biopsies obtained from lean volunteers were used to estimate content, mtDNA (markers of mitochondrial mass), -oxidase activity of mitochondrial electron transport chain (ETC) and activity of citrate synthase and beta-hydroxyacyl-CoA dehydrogenase (beta-HAD): key enzymes of TCA cycle and beta-oxidation pathway, respectively. |
3(0,0,0,3) | Details |
| 12119542 | Madej M, Lundh T, Lindberg JE: Activity of enzymes involved in energy production in the small intestine during suckling-weaning transition of pigs. Biol Neonate. 2002;82(1):53-60. The activity of citrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, dehydrogenase, alanine aminotransferase and aspartate aminotransferase was determined in the small intestine epithelium of piglets during suckling-weaning transition. |
2(0,0,0,2) | Details |
| 12456651 | Ruprich-Robert G, Zickler D, Berteaux-Lecellier V, Velot C, Picard M: Lack of mitochondrial citrate synthase discloses a new meiotic checkpoint in a strict aerobe. EMBO J. 2002 Dec 2;21(23):6440-51. |
2(0,0,0,2) | Details |
| 19479947 | Cheng TL, Liao CC, Tsai WH, Lin CC, Yeh CW, Teng CF, Chang WT: Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase. J Cell Biochem. 2009 Aug 1;107(5):1002-15. |
2(0,0,0,2) | Details |
| 19939938 | Ueki T, Lovley DR: Genome-wide gene regulation of biosynthesis and energy generation by a novel transcriptional repressor in Geobacter species. Nucleic Acids Res. 2010 Jan 1;38(3):810-21. Epub 2009 Nov 25. To better understand physiology of Geobacter species, expression and function of citrate synthase, a key enzyme in the TCA cycle that is important for organic acid oxidation in Geobacter species, was investigated. |
2(0,0,0,2) | Details |
| 14756538 | Appanna VD, Hamel R, Mackenzie C, Kumar P, Kalyuzhnyi SV: Adaptation of Pseudomonas fluorescens to Al- involvement of tricarboxylic acid and cycle enzymes and the influence of Curr Microbiol. 2003 Dec;47(6):521-7. While a six-fold increase in fumarase (FUM EC 4.2.1.2) activity was observed in cells subjected to Al- compared to control cells, citrate synthase (CS EC 4.1.3.7) activity experienced a two-fold increase. |
1(0,0,0,1) | Details |
| 16839657 | Chan M, Tan DS, Wong SH, Sim TS: A relevant in vitro eukaryotic live-cell system for the evaluation of plasmodial protein localization. Biochimie. 2006 Oct;88(10):1367-75. Epub 2006 Jun 22. These eukaryotic cells serve as an in vitro living system for studying the cellular destinations of four mitochondrial-targeted TCA cycle proteins (citrate synthase, CS; isocitrate dehydrogenase, ICDH; branched chain alpha-keto-acid dehydrogenase E1alpha subunit, BCKDH; succinate dehydrogenase flavoprotein-subunit, SDH), two nuclear-targeted proteins (histone deacetylase, HDAC; RNA polymerase, RPOL), two apicoplast-targeted proteins kinase 2, PK2; dehydrogenase, GDH), and two cytoplasmic resident proteins (malate dehydrogenase, MDH; glycerol kinase, GK). |
1(0,0,0,1) | Details |
| 19768502 | Soderberg MA, Cianciotto NP: Mediators of lipid A modification, RNA degradation, and central intermediary metabolism facilitate the growth of Legionella pneumophila at low temperatures. Curr Microbiol. 2010 Jan;60(1):59-65. Epub 2009 Sep 19. The proteins thereby implicated in low-temperature growth included components of the type II secretion system (LspE, LspG, LspH), a lipid A biosynthetic enzyme (LpxP), a ribonuclease (RNAse R), an RNA helicase (CsdA/DeaD), TCA cycle enzymes (citrate synthase), enzymes linked to fatty acid (FadB) or amino acid (aspartate aminotransferase) catabolism, and two putative membrane proteins that were, based upon their sequences, unlike previously characterized proteins. |
1(0,0,0,1) | Details |
| 19343341 | Imperlini E, Bianco C, Lonardo E, Camerini S, Cermola M, Moschetti G, Defez R: Effects of on Sinorhizobium meliloti survival and on symbiotic fixation and stem dry weight production. Appl Microbiol Biotechnol. 2009 Jun;83(4):727-38. Epub 2009 Apr 3. We assayed the activity of tricarboxylic acid cycle (TCA) key enzymes and found that activity of citrate synthase and alpha-ketoglutarate dehydrogenase were increased in both 1021+ and RD64 as compared to the wild-type strain. |
1(0,0,0,1) | Details |
| 17114264 | Tang Y, Pingitore F, Mukhopadhyay A, Phan R, Hazen TC, Keasling JD: Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris hildenborough using gas chromatography-mass spectrometry and Fourier transform-ion cyclotron resonance mass spectrometry. J Bacteriol. 2007 Feb;189(3):940-9. Epub 2006 Nov 17. FT-ICR MS was used to locate the labeled carbon distribution in and and confirmed the presence of an atypical enzyme for formation suggested in previous reports [the synthesized by this enzyme is the isotopic antipode of the synthesized by the (S)-citrate synthase]. |
1(0,0,0,1) | Details |
| 15121741 | Howarth KR, LeBlanc PJ, Heigenhauser GJ, Gibala MJ: Effect of endurance training on muscle TCA cycle metabolism during exercise in humans. J Appl Physiol. 2004 Aug;97(2):579-84. Epub 2004 Apr 30. In addition to improved performance, training increased (P < 0.05) peak uptake and citrate synthase maximal activity. |
1(0,0,0,1) | Details |
| 19053364 | Schiavon M, Ertani A, Nardi S: Effects of an alfalfa protein hydrolysate on the gene expression and activity of enzymes of the tricarboxylic acid (TCA) cycle and nitrogen metabolism in Zea mays L. J Agric Food Chem. 2008 Dec 24;56(24):11800-8. The activity of a number of enzymes involved in carbon (C) metabolism (malate dehydrogenase, MDH; isocitrate dehydrogenase, IDH; citrate synthase, CS) and N reduction and assimilation reductase, NR; reductase, NiR; glutamine synthetase, GS; synthase, GOGAT; aspartate aminotransferase, AspAT) was significantly induced by EM supply to plants, and the transcription pattern of MDH, IDH, CS, and NR strongly correlated with data of enzyme activity. |
1(0,0,0,1) | Details |
| 18683263 | Lee EG, Yoon SH, Das A, Lee SH, Li C, Kim JY, Choi MS, Oh DK, Kim SW: Directing vanillin production from by increased consumption in recombinant Escherichia coli. Biotechnol Bioeng. 2009 Jan 1;102(1):200-8. The amplification of gltA gene encoding citrate synthase of TCA cycle was required for the efficient conversion of generated during vanillin production from to which is essential for vanillin production. |
1(0,0,0,1) | Details |
| 19823102 | Mortensen OH, Olsen HL, Frandsen L, Nielsen PE, Nielsen FC, Grunnet N, Quistorff B: Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of Pediatr Res. 2010 Jan;67(1):47-53. In both tissues, citrate synthase activity remained unchanged. |
1(0,0,0,1) | Details |
| 12631716 | McCammon MT, Epstein CB, Przybyla-Zawislak B, McAlister-Henn L, Butow RA: Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes. Mol Biol Cell. 2003 Mar;14(3):958-72. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. |
1(0,0,0,1) | Details |
| 12138751 | Il'chenko AP, Cherniavskaia OG, Shishkanova NV, Finogenova TV: [Metabolism of Yarrowia lipolytica grown on under conditions promoting the production of alpha-ketoglutaric and citric acids: a comparative study of the central metabolism enzymes]. Mikrobiologiia. 2002 May-Jun;71(3):316-22. A comparative study of the enzymes of the tricarboxylic acid (TCA) and cycles in the mutant Yarrowia lipolytica strain N1 capable of producing alpha-ketoglutaric acid (KGA) and showed that almost all enzymes of the TCA cycle are more active under conditions promoting the production of KGA. The only exception was citrate synthase, whose activity was higher in yeast cells producing |
1(0,0,0,1) | Details |
| 16233247 | Lim SJ, Jung YM, Shin HD, Lee YH: Amplification of the -related genes zwf and gnd for the oddball biosynthesis of PHB in an E. coli transformant harboring a cloned phbCAB operon. J Biosci Bioeng. 2002;93(6):543-9. An excess of depressed cell growth mainly due to the inhibition of citrate synthase in the TCA cycle. |
1(0,0,0,1) | Details |
| 15989236 | Wang P, Zhuang YP, Chu J, Zhang SL: [Regulatory effects of ammonium ions on the biosynthesis of meilingmycin] . Wei Sheng Wu Xue Bao. 2005 Jun;45(3):405-9. The results suggest that glucose-6-phosphate dehydrogenase, citrate synthase, succinate dehydrogenase and fatty acid synthase are stimulated by higher concentration of ammonium ions, while dehydrogenase and carboxyltransferase are inhibited. |
1(0,0,0,1) | Details |
| 17341128 | Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E: Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 2007 Mar;4(3):e76. However, the activity of key mitochondrial enzymes of the TCA (tricarboxylic acid) cycle (citrate synthase), beta-oxidation (beta-hydroxyacyl-CoA dehydrogenase), and electron transport chain (cytochrome C oxidase II) was unchanged. |
1(0,0,0,1) | Details |
| 15334410 | Mancuso A, Beardsley NJ, Wehrli S, Pickup S, Matschinsky FM, Glickson JD: Real-time detection of 13C NMR labeling kinetics in perfused EMT6 mouse mammary tumor cells and betaHC9 mouse insulinomas. Biotechnol Bioeng. 2004 Sep 30;87(7):835-48. Citrate synthase activity was indirectly detected in real time, as [3,4-13C2] was formed from [2-13C] and [2-13C] (of |
1(0,0,0,1) | Details |
| 15158257 | Peng L, Arauzo-Bravo MJ, Shimizu K: Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurements. FEMS Microbiol Lett. 2004 Jun 1;235(1):17-23. Some TCA cycle enzymes such as citrate synthase, aconitase and malate dehydrogenase were also upregulated, but enzymes of glycolysis and the pentose phosphate pathway were downregulated. |
1(0,0,0,1) | Details |
| 12125093 | Bacurau RF, O'Toole CE, Newsholme P, Costa Rosa LF: Sub-lethal concentrations of activated complement increase rat lymphocyte utilization and oxidation while lethal concentrations cause death by a mechanism involving ATP depletion. Cell Biochem Funct. 2002 Sep;20(3):183-90. We have measured the maximum activity of hexokinase, citrate synthase, glucose 6-phosphate dehydrogenase and glutaminase in rat mesenteric lymphocytes exposed to sub-lethal concentrations of activated complement (present in zymosan-activated serum, ZAS). |
1(0,0,0,1) | Details |
| 18338221 | Ojima Y, Nishioka M, Taya M: Metabolic alternations in SOD-deficient Escherichia coli cells when cultivated under oxidative stress from photoexcited titanium dioxide. Biotechnol Lett. 2008 Jun;30(6):1107-13. Epub 2008 Mar 13. Under the stress condition, the activity of kinase and mRNA expressions of the enzymes for production (pta and ackA) were approximately doubled, while the activity of citrate synthase and mRNA expressions of the enzymes in TCA cycle (gltA, acnA, icd, sucA, sucC, sdhA, fumA and mdh) were repressed by about half, as compared with those under the normal condition. |
1(0,0,0,1) | Details |
| 15561107 | Miceli MV, Jazwinski SM: Common and cell type-specific responses of human cells to mitochondrial dysfunction. Exp Cell Res. 2005 Jan 15;302(2):270-80. Gene expression changes that were common to all three cell types included up-regulation of GCK (glucokinase), CS (citrate synthase), HOX1 (heme oxygenase 1), CKMT2 (mitochondrial kinase 2), MYC (v-myc myelocytomatosis viral oncogene homolog), and WRN (Werner syndrome helicase), and down-regulation of FBP1 -1, 6-bisphosphatase 1) and COL4A1 (collagen, type IV, alpha 1). |
1(0,0,0,1) | Details |
| 16395550 | Blencke HM, Reif I, Commichau FM, Detsch C, Wacker I, Ludwig H, Stulke J: Regulation of citB expression in Bacillus subtilis: integration of multiple metabolic signals in the pool and by the general regulatory system. Arch Microbiol. 2006 Mar;185(2):136-46. Epub 2006 Jan 5. The syntheses of the enzymes performing the initial reactions of the cycle, citrate synthase, and aconitase, are synergistically repressed by rapidly metabolizable carbon sources and |
1(0,0,0,1) | Details |
| 16980490 | Noda S, Takezawa Y, Mizutani T, Asakura T, Nishiumi E, Onoe K, Wada M, Tomita F, Matsushita K, Yokota A: Alterations of cellular physiology in Escherichia coli in response to oxidative phosphorylation impaired by defective F1-ATPase. J Bacteriol. 2006 Oct;188(19):6869-76. Genetic and biochemical analyses of the mutant revealed the downregulation of many TCA cycle enzymes, including citrate synthase, and the upregulation of the pyruvate dehydrogenase complex in both transcription and enzyme activities. |
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| 17316901 | Morland C, Henjum S, Iversen EG, Skrede KK, Hassel B: Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochem Int. 2007 Apr;50(5):703-9. Epub 2007 Jan 20. In contrast, formation of from [U-(14) C] in awake rats (which reflects the passage of (14) C through the whole TCA cycle) and activities of pyruvate dehydrogenase, citrate synthase, alpha-ketoglutarate dehydrogenase, and fumarase in white structures were 10-23% of cortical values, optic nerve showing the lowest values. |
1(0,0,0,1) | Details |
| 16987018 | Ago T, Yeh I, Yamamoto M, Schinke-Braun M, Brown JA, Tian B, Sadoshima J: Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1635-50. The activity of citrate synthase and COX and the cardiac ATP content were significantly higher in Tg-Trx1. |
1(0,0,0,1) | Details |