Protein Information

Name hexosaminidase
Synonyms Beta N acetylhexosaminidase; Beta hexosaminidase A; Beta hexosaminidase alpha chain; Beta hexosaminidase alpha chain precursor; HEXA; HEXA protein; Hexosaminidase A; Hexosaminidase A preproprotein variant…

Compound Information

Name benzalkonium chloride
CAS quaternary ammonium compounds, alkylbenzyldimethyl, chlorides

Reference List

PubMed Abstract RScore(About this table)
1607234 Williams DE, Nguyen KD, Shapourifar-Tehrani S, Kitada S, Lee DA: Effects of timolol, betaxolol, and levobunolol on human tenon's fibroblasts in tissue culture. Invest Ophthalmol Vis Sci. 1992 Jun;33(7):2233-41.

To investigate this question further, the antiproliferative effects of the preservative benzalkonium chloride and three pure and commercially available beta-adrenergic antagonist preparations (timolol, betaxolol, and levobunolol) were studied on tissue cultures of human Tenon's capsule fibroblasts.
Fibroblast growth was measured with tritiated thymidine uptake and hexosaminidase assays.
1(0,0,0,1) Details
12130703 Stenton GR, Nohara O, Dery RE, Vliagoftis H, Gilchrist M, Johri A, Wallace JL, Hollenberg MD, Moqbel R, Befus AD: Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. J Pharmacol Exp Ther. 2002 Aug;302(2):466-74.

Using benzalkonium chloride, which antagonizes the actions of 48/80 by competing for the same G (i) protein, we determined that benzalkonium chloride suppressed tc-LIGRLO-NH (2)-mediated (0.1 microM) beta-hexosaminidase release by 62%.
34(0,1,1,4) Details