Protein Information

Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
17288499 Seger DL: A critical reconsideration of the clinical effects and treatment recommendations for sodium channel blocking drug cardiotoxicity. Toxicol Rev. 2006;25(4):283-96.

5(0,0,0,5) Details
15275796 Barnet CS, Tse JY, Kohane DS: Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. Pain. 2004 Jul;110(1-2):432-8.

3(0,0,0,3) Details
17697824 Bebarta VS, Phillips S, Eberhardt A, Calihan KJ, Waksman JC, Heard K: Incidence of Brugada electrocardiographic pattern and outcomes of these patients after intentional tricyclic antidepressant ingestion. Am J Cardiol. 2007 Aug 15;100(4):656-60. Epub 2007 Jun 26.


Brugada syndrome is a genetic dysfunction of the myocardial sodium channel that leads to ventricular dysrhythmias.
1(0,0,0,1) Details
19636245 Palaniswamy C, Selvaraj DR, Chugh T, Singh T, Khalique O, Tsai F, Sandhu R: Brugada Electrocardiographic Pattern Induced by Amitriptyline Overdose: A Case Report. Am J Ther. 2009 Jul 24.


The principal mechanism of toxicity is cardiac sodium channel blockade.
1(0,0,0,1) Details