Protein Information

Name leptin
Synonyms LEP; Leptin; Leptin precursor; OB; OBS; Obese protein; Obesity factor; leptin (murine obesity homolog)…

Compound Information

Name TCA
CAS 2,2,2-trichloroacetic acid

Reference List

PubMed Abstract RScore(About this table)
16891627 Fenton JI, Hursting SD, Perkins SN, Hord NG: Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. Carcinogenesis. 2007 Feb;28(2):455-64. Epub 2006 Aug 4.

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15165567 McMurtry JP, Ashwell CM, Brocht DM, Caperna TJ: Plasma clearance and tissue distribution of radiolabeled leptin in the chicken. Comp Biochem Physiol A Mol Integr Physiol. 2004 May;138(1):27-32.

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16259293 Rivera-Gallardo MT, Ma del Socorro PC, Barriguete-Melendez JA: [Eating disorders as risk factors for osteoporosis] . Salud Publica Mex. 2005 Jul-Aug;47(4):308-18.


The mechanisms implied in the pathogenesis of bone loss are the hypoestrogenism, hypercortisolism, serum leptin levels and insulin-like growth factor decrease.
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14559057 Wlodek D, Gonzales M: Decreased energy levels can cause and sustain obesity. J Theor Biol. 2003 Nov 7;225(1):33-44.


Further steps in obesity development are the consequences of diminished energy supply: inhibition of beta-oxidation, leptin resistance, increase in appetite and food intake and a decrease in physical activity.
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16389718 Ruetsch O, Viala A, Bardou H, Martin P, Vacheron MN: [Psychotropic drugs induced weight gain: a review of the literature concerning epidemiological data, mechanisms and management]. Encephale. 2005 Jul-Aug;31(4 Pt 1):507-16.


According to current concepts, appetite and feeding are regulated by a complex of neurotransmitters, neuromodulators, cytokines and hormones interacting with the hypothalamus, including the leptin and the tumor necrosis factor system.
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