| Name | endothelin 1 |
|---|---|
| Synonyms | EDN 1; EDN1; ET1; Endothelin 1; Endothelin 1 precursor; PPET 1; PPET1; Preproendothelin 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18275597 | Cullingford TE, Markou T, Fuller SJ, Giraldo A, Pikkarainen S, Zoumpoulidou G, Alsafi A, Ekere C, Kemp TJ, Dennis JL, Game L, Sugden PH, Clerk A: Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes. Genome Biol. 2008;9(2):R32. Epub 2008 Feb 14. RESULTS: Using microarrays, we defined the early transcriptional responses of neonatal rat cardiomyocytes to endothelin-1 over 4 h, differentiating between immediate early gene (IEG) and second phase RNAs with cycloheximide. |
9(0,0,1,4) | Details |
| 18406357 | Cullingford TE, Butler MJ, Marshall AK, Tham el L, Sugden PH, Clerk A: Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25. All were regulated as immediate early genes (cycloheximide did not inhibit the increases in expression). |
5(0,0,0,5) | Details |
| 19878520 | Ohuchi N, Hayashi K, Iwamoto K, Koike K, Kizawa Y, Nukaga M, Kakegawa T, Murakami H: Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts. Fundam Clin Pharmacol. 2009 Oct 30. Thrombin (2.5 U/mL) induced an increase in immunoreactive ET-1 expression, which was inhibited by cycloheximide (10 mug/mL), and an increase in preproET-1 mRNA expression, as assessed by reverse transcription polymerase chain reaction. |
2(0,0,0,2) | Details |
| 19188658 | Kulasekaran P, Scavone CA, Rogers DS, Arenberg DA, Thannickal VJ, Horowitz JC: Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation. Am J Respir Cell Mol Biol. 2009 Oct;41(4):484-93. Epub 2009 Feb 2. |
1(0,0,0,1) | Details |
| 17643133 | Raoch V, Martinez-Miguel P, Arribas-Gomez I, Rodriguez-Puyol M, Rodriguez-Puyol D, Lopez-Ongil S: The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1. Br J Pharmacol. 2007 Oct;152(3):313-22. Epub 2007 Jul 23. Cycloheximide abolished that effect. |
1(0,0,0,1) | Details |
| 16725137 | Eskesen K, Edvinsson L: Upregulation of endothelin ETB receptor-mediated vasoconstriction in rat coronary artery after organ culture. Eur J Pharmacol. 2006 Jun 13;539(3):192-4. Epub 2006 May 3. Presence of contractile endothelin ET (B) receptors was studied by measuring the change in isometric tension in rings of left anterior descending coronary arteries isolated from hearts of rats as response to application of the selective endothelin ET (B) receptor agonist, Sarafotoxin 6c and endothelin-1. The increased contraction to Sarafotoxin 6c after culturing could be eliminated with addition of the transcriptional blocker, actinomycin D, to the culture medium or be significantly attenuated by application of the translational inhibitor, cycloheximide. |
1(0,0,0,1) | Details |
| 20237589 | Hill BJ, Gebre S, Schlicker B, Jordan R, Necessary S: Nongenomic inhibition of coronary constriction by 17beta- and Can J Physiol Pharmacol. 2010 Feb;88(2):147-52. The protein synthesis inhibitor cycloheximide and the estrogen receptor antagonists ICI 182780 and tamoxifen did not affect the attenuation. Moreover, E2, 2-HOE, and 2-MeOH antagonized the contraction induced by the vasospasm agonist endothelin-1 (0.1 micromol/L) by approximately 36%. |
1(0,0,0,1) | Details |
| 18312133 | Menzies-Gow NJ, Bailey SR, Berhane Y, Brooks AC, Elliott J: Evaluation of the induction of vasoactive mediators from equine digital vein endothelial cells by endotoxin. Am J Vet Res. 2008 Mar;69(3):349-55. The EDVECs were incubated for 18 hours with LPS (10 pg/mL to 1 microg/mL) with or without cycloheximide, or L-nitroarginine methyl ester. Medium concentrations of cyclic endothelin-1, and A (2) were determined. |
1(0,0,0,1) | Details |
| 20339118 | Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM: Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via /Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circ Res. 2010 Mar 25. Effects were inhibited by actinomycin D and cycloheximide and blunted by calmidazolium and low extracellular Ca (2+) ([Ca (2+)] e). |
1(0,0,0,1) | Details |
| 16539723 | Granstrom BW, Xu CB, Nilsson E, Vikman P, Edvinsson L: Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi. BMC Pulm Med. 2006 Mar 15;6:6. The up-regulation of their contractility was blunted by cycloheximide treatment, a translational inhibitor. Contractile responses to sarafotoxin 6c (a selective agonist for ETB receptors) and endothelin-1 (an ETA and ETB receptor agonist) were studied by use of a sensitive myograph. |
1(0,0,0,1) | Details |
| 15668985 | Kwok CF, Juan CC, Shih KC, Hwu CM, Jap TS, Ho LT: Insulin-like growth factor-1 increases endothelin receptor A levels and action in cultured rat aortic smooth muscle cells. J Cell Biochem. 2005 Apr 15;94(6):1126-34. These effects of IGF-1 were abolished by cycloheximide or |
0(0,0,0,0) | Details |