Protein Information

Name NFIL3
Synonyms E4BP4; E4BP4 protein; IL3BP1; NF IL3A; NFIL 3; NFIL3; NFIL3 protein; NFIL3A…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
20080759 Kashiwada M, Levy DM, McKeag L, Murray K, Schroder AJ, Canfield SM, Traver G, Rothman PB: IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):821-6. Epub 2009 Dec 22.

Expression of NFIL3 in NFIL3-deficient B cells restores the impairment of IgE production, and overexpression of NFIL3 in the presence of cycloheximide induces GLepsilon transcripts.
88(1,1,1,8) Details
17193924 Hu LY, Tepper CG, Lo SH, Lin WC: An efficient strategy to identify early TPA-responsive genes during differentiation of HL-60 cells. Gene Expr. 2006;13(3):179-89.

This was performed in cells that were synchronized by nocodazole and treated with TPA in the presence of a protein synthesis inhibitor, cycloheximide, to prevent activation of secondary targets and therefore increase the probability of early transcripts in total RNA pool.
Furthermore, upregulation of three candidate genes (NFIL3, SKIL, and JMJD3) was shown to be dosage and time dependent with TPA treatment and was found to be directly regulated by TPA through PKC-dependent signaling.
1(0,0,0,1) Details