| Name | insulin like growth factor I |
|---|---|
| Synonyms | IBP1; MGF; IBP1; IGF 1; IGF IA; IGF IB; IGF1; IGFI… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16899596 | Catrina SB, Botusan IR, Rantanen A, Catrina AI, Pyakurel P, Savu O, Axelson M, Biberfeld P, Poellinger L, Brismar K: Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I. Clin Cancer Res. 2006 Aug 1;12(15):4506-14. The induction suggests a translation mechanism as documented by cycloheximide chase experiment coupled with constant RNA levels as evaluated by quantitative real-time PCR. |
1(0,0,0,1) | Details |
| 19183465 | Gentilini A, Lottini B, Brogi M, Caligiuri A, Cosmi L, Marra F, Pinzani M: Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells. Fibrogenesis Tissue Repair. 2009 Jan 30;2(1):1. |
1(0,0,0,1) | Details |
| 18055878 | Murray IA, Perdew GH: stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther. 2008 Mar;324(3):1102-10. Epub 2007 Nov 30. Here, we have examined the effect of nonclassical, i.e., nonligand binding, AhR activation by upon human insulin-like growth factor binding protein (hIGFBP)-1, a secreted phosphoprotein involved in regulation of insulin-like growth factor-I/II bioavailability and mitogenic activity. Cotreatment with cycloheximide further suggests a direct transcriptional role for hAhR at the hIGFBP-1 promoter. |
1(0,0,0,1) | Details |
| 15647455 | Weber GM, Sullivan CV: Insulin-like growth factor-I induces oocyte maturational competence but not meiotic resumption in white bass (Morone chrysops) follicles in vitro: evidence for rapid evolution of insulin-like growth factor action. Biol Reprod. 2005 May;72(5):1177-86. Epub 2005 Jan 12. A combination of recombinant human (rh) insulin-like growth factor-I (IGF-I) (25 nM) and the maturation-inducing hormone (MIH), 17,20beta,21-trihydroxy-4-pregnen-3-one (20beta-S; 72.5 nM), induced germinal vesicle breakdown (GVBD) in ovarian follicles of white bass incubated in vitro, whereas a four times greater concentration of each hormone was ineffective alone. |
1(0,0,0,1) | Details |
| 16531089 | Mukherjee D, Mukherjee D, Sen U, Paul S, Bhattacharyya SP: In vitro effects of insulin-like growth factors and insulin on oocyte maturation and maturation-inducing steroid production in ovarian follicles of common carp, Cyprinus carpio. Comp Biochem Physiol A Mol Integr Physiol. 2006 May;144(1):63-77. Epub 2006 Mar 10. Cycloheximide was shown to inhibit the induction of GVBD and DHP production by IGF-I, b-insulin and HCG. In vitro germinal vesicle breakdown (GVBD) in Cyprinus carpio oocytes was induced by recombinant human insulin-like growth factor-I and -II (IGF-I and IGF-II) and bovine insulin (b-insulin). |
1(0,0,0,1) | Details |
| 17879768 | Triplett JW, O'Riley R, Tekulve K, Norvell SM, Pavalko FM: Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner. Mol Cell Biomech. 2007 Mar;4(1):13-25. We found that insulin-like growth factor-I (IGF-I) was significantly more effective at preventing TNF-alpha-induced apoptosis when cells were first subjected to mechanical loading by exposure to either unidirectional or oscillatory fluid flow compared to cells that were maintained in static culture. |
1(0,0,0,1) | Details |
| 18327666 | Yamaguchi M, Goto M, Uchiyama S, Nakagawa T: Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions. Mol Cell Biochem. 2008 May;312(1-2):157-66. Epub 2008 Mar 9. The effect of zinc on the mRNA expressions in Runx2, osteocalcin, alpha1 (I) collagen, insulin-like growth factor-I (IGF-I), transforming growth factor-beta1 (TGF-beta1), osteoprotegerin (OPG), regucalcin, zinc transporter 1 (ZIP1), or glyceroaldehyde-3- dehydrogenase (G3PDH) in osteoblastic MC3T3-E1 cells in vitro was investigated. The stimulatory effects of zinc on Runx2, OPG, or regucalcin mRNAs were significantly prevented in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole (10 (-6) M), an inhibitor of transcription activity. |
1(0,0,0,1) | Details |
| 15547677 | Ishida K, Yamaguchi M: Role of albumin in osteoblastic cells: enhancement of cell proliferation and suppression of alkaline phosphatase activity. Int J Mol Med. 2004 Dec;14(6):1077-81. Also, the stimulating effect of albumin on cell proliferation was completely prevented in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), an inhibitor of transcriptional activity. |
0(0,0,0,0) | Details |
| 20035463 | Sarang MK, Lal B: Effect of piscine GH/IGF-I on final oocyte maturation in vitro in Heteropneustes fossilis. Fish Physiol Biochem. 2005 Apr;31(2-3):231-3. Incubation of ovarian tissue with GH in the presence of actinomycin D: or cycloheximide or barramundi IGF-I antiserum was also made separately. |
0(0,0,0,0) | Details |
| 16405511 | Broccolini A, Gidaro T, Morosetti R, Gliubizzi C, Servidei T, Pescatori M, Tonali PA, Ricci E, Mirabella M: Neprilysin participates in skeletal muscle regeneration and is accumulated in abnormal muscle fibres of inclusion body myositis. J Neurochem. 2006 Feb;96(3):777-89. Epub 2006 Jan 9. Therefore, NEP may play an important role during muscle cell differentiation, possibly through the regulation, either directly or indirectly, of the insulin-like growth factor I-driven myogenic programme. |
2(0,0,0,2) | Details |
| 18437163 | Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D: Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell Death Differ. 2008 Aug;15(8):1304-17. Epub 2008 Apr 25. |
2(0,0,0,2) | Details |
| 17320084 | Weber GM, Moore AB, Sullivan CV: In vitro actions of insulin-like growth factor-I on ovarian follicle maturation in white perch (Morone americana). Gen Comp Endocrinol. 2007 Apr;151(2):180-7. Epub 2007 Jan 20. |
2(0,0,0,2) | Details |
| 15754031 | Uchiyama S, Yamaguchi M: stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1 cells. Int J Mol Med. 2005 Apr;15(4):675-81. The stimulatory effect of (10 (-6) M) on cellular biochemical components was completely prevented in the presence of cycloheximide (10 (-6) M), an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 10 (-9) M), an inhibitor of transcriptional activity. The expressions of insulin-like growth factor (IGF)-I and transforming growth factor (TGF)-beta1 mRNAs were demonstrated by reverse transcription-polymerase chain reaction (RT-PCR) analysis in osteoblastic cells using mouse IGF-I or TGF-beta1-specific primers. |
1(0,0,0,1) | Details |
| 16820941 | Otomo Y, Yamaguchi M: Regulatory effect of exogenous regucalcin on cell function in osteoblastic MC3T3-E1 cells: involvement of intracellular signaling factor. Int J Mol Med. 2006 Aug;18(2):321-7. The effect of regucalcin in decreasing cellular protein content was seen in the presence of insulin-like growth factor-I (IGF-I; 10 (-9) or 10 (-8) M). The presence of regucalcin did not have a significant effect on protein and DNA contents in the cells cultured with cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro -1-beta-D-ribofuranosylbenzimidazole (10 (-6) M), an inhibitor of transcription activity; which each inhibitor caused a significant decrease in those contents. |
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