| Name | cyclin dependent kinase inhibitor p27 |
|---|---|
| Synonyms | CDKN 4; CDKN1B; CDKN4; Cyclin dependent kinase inhibitor 1B; Cyclin dependent kinase inhibitor p27; KIP 1; KIP1; P27KIP1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15545300 | Jaruga-Killeen E, Rayford W: TNF receptor 1 is involved in the induction of apoptosis by the cyclin dependent kinase inhibitor p27Kip1 in the prostate cancer cell line PC-3. FASEB J. 2005 Jan;19(1):139-41. Epub 2004 Nov 15. Cell cycle and typical markers of apoptosis were analyzed by flow cytometry in the presence of the following reagents: cycloheximide, pan-caspase inhibitor ZVAD-fmk, neutralizing anti-TNFR1, and anti-TNFR2. |
5(0,0,0,5) | Details |
| 16407831 | Taube ME, Liu XW, Fridman R, Kim HR: TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27 (KIP1) protein. Oncogene. 2006 May 18;25(21):3041-8. |
4(0,0,0,4) | Details |
| 15870436 | Van Dross R, Yao S, Asad S, Westlake G, Mays DJ, Barquero L, Duell S, Pietenpol JA, Browning PJ: Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells. J Natl Cancer Inst. 2005 May 4;97(9):656-66. METHODS: We used immunoprecipitation with K-cyclin antibodies to examine the association of K-cyclin with cdk2, cdk6, p21Cip1, and p27Kip1 proteins in BC3 cells. The half-life of K-cyclin and cyclin D2 proteins was determined by blocking protein synthesis with cycloheximide and measuring proteins in cell lysates by western blot analysis. |
2(0,0,0,2) | Details |
| 19591933 | Mishra A, Godavarthi SK, Jana NR: UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27. Neurobiol Dis. 2009 Oct;36(1):26-34. Epub 2009 Jul 8. Here, we show that E6-AP interacts with and promotes proteasome-mediated degradation of cyclin-dependent kinase inhibitor p27. |
1(0,0,0,1) | Details |
| 17338678 | Shenkman M, Tolchinsky S, Kondratyev M, Lederkremer GZ: Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response. Biochem J. 2007 Jun 15;404(3):509-16. However, we found that in its early stages the UPR leads to a transient inhibition of proteasomal disposal of cytosolic substrates (p53 and p27kip1) and of those targeted to ER (endoplasmic reticulum)-associated degradation (uncleaved precursor of asialoglycoprotein receptor H2a). |
1(0,0,0,1) | Details |
| 16313905 | Christman SA, Kong BW, Landry MM, Kim H, Foster DN: Modulation of p53 expression and its role in the conversion to a fully immortalized chicken embryo fibroblast line. FEBS Lett. 2005 Dec 19;579(30):6705-15. Epub 2005 Nov 21. Other p53-related genes including p21WAF1, p27Kip1, MDM-2, and the p16INK4a alternate reading frame (ARF) sequence showed similar patterns of differential mRNA expression. |
1(0,0,0,1) | Details |
| 16859513 | Shapira M, Kakiashvili E, Rosenberg T, Hershko DD: The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells. Breast Cancer Res. 2006;8(4):R46. INTRODUCTION: Loss of the cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in breast cancer. The effect of rapamycin on the degradation rate of Skp2 expression was examined in cycloheximide-treated cells and in relationship to the anaphase promoting complex/Cdh1 (APC\C) inhibitor Emi1. |
1(0,0,0,1) | Details |