| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17316563 | Sakata Y, Yoshioka W, Tohyama C, Ohsako S: Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide. Biochem Biophys Res Commun. 2007 Apr 13;355(3):687-92. Epub 2007 Feb 9. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces CYP1A1 mRNA expression, and co-treatment with the protein synthesis inhibitor, cycloheximide (CHX) magnifies its expression severalfold further. |
90(1,1,2,5) | Details |
| 17606337 | Elbekai RH, El-Kadi AO: Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and Toxicol Lett. 2007 Aug;172(3):106-19. Epub 2007 May 24. The metal-mediated induction of Cyp1a1 mRNA was further potentiated by the protein synthesis inhibitor, cycloheximide and the 26S proteasome inhibitor, MG-132, but completely inhibited by the RNA transcription inhibitor, actinomycin-D, implying a transcriptional regulation of the Cyp1a1 gene by the heavy metals. |
90(1,1,1,10) | Details |
| 15837795 | Beischlag TV, Perdew GH: ER alpha-AHR-ARNT protein-protein interactions mediate -dependent transrepression of dioxin-inducible gene transcription. J Biol Chem. 2005 Jun 3;280(22):21607-11. Epub 2005 Apr 18. Both AHR and ARNT were capable of interacting directly with ER alpha, as ascertained by glutathione S-transferase pull-down. 17Beta- repressed TCDD-activated Cyp1a1 and Cyp1b1 gene transcription in MCF-7 cells in the presence of cycloheximide, as determined by reverse transcription/real-time PCR. |
34(0,1,1,4) | Details |
| 18729741 | Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K: Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line. J Interferon Cytokine Res. 2008 Aug;28(8):509-21. When human fibroblast-like synoviocytes line MH7A was treated with cigarette smoke condensate (CSC), either mainstream or sidestream, expression levels of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and CYP1A1 mRNA were upregulated in both time- and dose-dependent manners. Cycloheximide treatment indicated that the augmenting effect of CSC on IL-1alpha, IL-1beta and IL-8, but not IL-6 and CYP1A1, mRNA expression requires de novo protein synthesis. |
1(0,0,0,1) | Details |
| 16243960 | Korashy HM, El-Kadi AO: Transcriptional regulation of the NAD (P) H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and Drug Metab Dispos. 2006 Jan;34(1):152-65. Epub 2005 Oct 21. To investigate the molecular mechanisms involved in the regulation of Nqo1 and Gst ya genes by heavy metals, Hepa 1c1c7 cells were treated with Hg2+, Pb2+, or Cu2+ in the presence and absence of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of Nqo1, Gst ya, and Cyp1a1 genes. The protein synthesis inhibitor cycloheximide significantly inhibited metal-mediated induction of Nqo1 and Gst ya mRNAs, which coincided with a decrease in the nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression, implying the requirement of Nrf2 protein synthesis for the induction of these genes. |
1(0,0,0,1) | Details |
| 18055878 | Murray IA, Perdew GH: stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther. 2008 Mar;324(3):1102-10. Epub 2007 Nov 30. 5-Methoxy-2-{(4-methoxy-3,5-dimethyl-pyridin-2-yl) methylsulfinyl}-3H-benzo a benzoimidazole-derived gastric H (+)/K (+)-ATPase proton pump inhibitor (PPI) extensively prescribed for the treatment of gastroesophageal acid reflux disease, can stimulate the expression of CYP1A1 via activation of the human aryl hydrocarbon receptor (hAhR) in an apparent nonligand-binding manner. Cotreatment with cycloheximide further suggests a direct transcriptional role for hAhR at the hIGFBP-1 promoter. |
1(0,0,0,1) | Details |
| 16093525 | Korashy HM, El-Kadi AO: Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals. Toxicol Sci. 2005 Nov;88(1):39-51. Epub 2005 Aug 10. The protein synthesis inhibitor, cycloheximide, and 26S proteasome inhibitor, carbobenzoxy-L-leucyl-L-leucyl-leucinal (MG-132), super-induced the metal-mediated induction of Cyp1a1 mRNA. |
90(1,1,1,10) | Details |
| 15608132 | Gharavi N, El-Kadi AO: tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand. . Drug Metab Dispos. 2005 Mar;33(3):365-72. Epub 2004 Dec 17. The protein synthesis inhibitor cycloheximide superinduced the tBHQ-mediated induction of Cyp1a1 mRNA and completely prevented the increase in Cyp1a1 activity, indicating that the induction of enzyme activity by tBHQ is dependent on de novo protein synthesis. |
88(1,1,1,8) | Details |
| 16426572 | Zhang ZY, Pelletier RD, Wong YN, Sugawara M, Zhao N, Littlefield BA: Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells. Biochem Biophys Res Commun. 2006 Mar 10;341(2):399-407. Epub 2006 Jan 11. Moreover, while both genes were up-regulated by TCDD in primary hepatocytes and HepG2 cells, the induction of CYP1A1 and CYP1A2 at the mRNA level was distinguishable, indicated by the marked differences in activation kinetics and the response to the protein synthesis inhibitors, anisomycin and cycloheximide. |
34(0,1,1,4) | Details |
| 17599377 | Khan S, Liu S, Stoner M, Safe S: Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells. Toxicol Appl Pharmacol. 2007 Aug 15;223(1):28-38. Epub 2007 May 25. Cotreatment of ZR-75 cells with TCDD plus the protein synthesis inhibitor cycloheximide for 6 h enhanced CYP1A1 expression in cells grown under hypoxia and normoxia. |
32(0,1,1,2) | Details |
| 20108032 | Chopra M, Gahrs M, Haben M, Michels C, Schrenk D: Inhibition of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin depends on protein biosynthesis. Cell Biol Toxicol. 2010 Jan 27. Since both of these compounds inhibit protein biosynthesis as was demonstrated by measuring the incorporation of radiolabeled leucin and protein expression of cytochrome P450 1A1, we propose that the inhibition of apoptosis by TCDD depends on protein biosynthesis. In this study, we examined the effects of TCDD on apoptosis induced by UV-C light, ochratoxin A (OTA), and cycloheximide (CHX) in primary rat hepatocytes. |
1(0,0,0,1) | Details |
| 16226227 | Pollenz RS, Popat J, Dougherty EJ: Role of the carboxy-terminal transactivation domain and active transcription in the ligand-induced and ligand-independent degradation of the mouse Ahb-1 receptor. Biochem Pharmacol. 2005 Nov 25;70(11):1623-33. Epub 2005 Oct 13. To assess the importance of transactivation domains (TAD), DNA binding and transcription on the degradation of the AH receptor (AHR), Hepa-1 cells were pre-treated with actinomycin D (AD) or cycloheximide (CHX) and exposed to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD). Cells expressing AHR (640) induced CYP1A1 protein to 50% of the level of cells expressing wild type AHR and exhibited significant degradation of AHR (640). |
1(0,0,0,1) | Details |
| 16466815 | Aluru N, Vijayan MM: affects CYP1A expression in rainbow trout hepatocytes. . Aquat Toxicol. 2006 May 10;77(3):291-7. Epub 2006 Feb 8. This higher protein response with RVT was completely abolished with actinomycin D and cycloheximide suggesting transcriptional and translational regulation of CYP1A induction. |
0(0,0,0,0) | Details |
| 19041363 | Asare N, Lag M, Lagadic-Gossmann D, Rissel M, Schwarze P, Holme JA: 3-Nitrofluoranthene (3-NF) but not 3-aminofluoranthene (3-AF) elicits apoptosis as well as programmed necrosis in Hepa1c1c7 cells. Toxicology. 2009 Jan 31;255(3):140-50. Epub 2008 Nov 7. Cycloheximide completely attenuated 3-NF-induced cell death. |
0(0,0,0,0) | Details |