| Name | TIMP 1 |
|---|---|
| Synonyms | CLGI; Collagenase inhibitor; EPA; EPO; Erythroid potentiating activity; Fibroblast collagenase inhibitor; HCI; Metalloproteinase inhibitor 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18029162 | Sampieri CL, Nuttall RK, Young DA, Goldspink D, Clark IM, Edwards DR: Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biol. 2008 Mar;27(2):128-38. Epub 2007 Oct 4. The involvement of the p38 and JNK pathways in the selective effects of anisomycin and cycloheximide on MMP/TIMP expression was supported by use of pharmacological inhibitors. |
34(0,1,1,4) | Details |
| 15659777 | Boulday G, Fitau J, Coupel S, Soulillou JP, Charreau B: Exogenous tissue inhibitor of metalloproteinase-1 promotes endothelial cell survival through activation of the phosphatidylinositol 3-kinase/Akt pathway. Ann N Y Acad Sci. 2004 Dec;1030:28-36. We demonstrate that exogenous, recombinant, TIMP-1 efficiently prevents apoptosis induced by TNFalpha in cycloheximide-sensitized ECs. |
12(0,0,1,7) | Details |
| 16407831 | Taube ME, Liu XW, Fridman R, Kim HR: TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27 (KIP1) protein. Oncogene. 2006 May 18;25(21):3041-8. |
8(0,0,0,8) | Details |
| 16514055 | Gu BJ, Wiley JS: Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. Blood. 2006 Jun 15;107(12):4946-53. Epub 2006 Mar 2. In this study, ATP caused a rapid release of MMP-9 and a moderate decrease in tissue inhibitor of metalloproteinase 1 (TIMP-1) release from human peripheral-blood mononuclear cells (PBMCs) over a 30-minute time course. ATP-induced MMP-9 release was inhibited by the P2X (7) receptor antagonists periodate oxidized ATP and KN-62, or by chelators, as well as by a loss-of-function polymorphism in the P2X (7) receptor, but not by brefeldin A, monensin, or cycloheximide, or by anti-tumor necrosis factor-alpha (TNF-alpha) or anti-interleukin-1beta (IL-1beta) monoclonal antibodies. |
2(0,0,0,2) | Details |
| 19580633 | Hartland SN, Murphy F, Aucott RL, Abergel A, Zhou X, Waung J, Patel N, Bradshaw C, Collins J, Mann D, Benyon RC, Iredale JP: Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin. Liver Int. 2009 Aug;29(7):966-78. During spontaneous recovery from experimental liver fibrosis, the expression of TIMP-1 declines and hepatic collagenolytic activity increases. |
1(0,0,0,1) | Details |