Protein Information

Name SF 1
Synonyms AD4BP; Adrenal 4 binding protein; ELP; FTZ 1; FTZ1; FTZF 1; FTZF1; Fushi tarazu factor homolog 1…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16353668 Lehmann TP, Biernacka-Lukanty JM, Trzeciak WH, Li JY: Steroidogenic factor 1 gene transcription is inhibited by transforming growth factor beta. Endocr Res. 2005;31(2):71-9.

Inhibition of Sf-1 expression by TGF-beta was abolished by cycloheximide, suggesting that the growth factor inhibitory effect requires ongoing protein synthesis.
36(0,1,1,6) Details
15912208 Lehmann TP, Biernacka-Lukanty JM, Saraco N, Langlois D, Li JY, Trzeciak WH: Temporal pattern of the induction of SF-1 gene expression by the signal transduction pathway involving 3',5'-cyclic adenosine monophosphate. Acta Biochim Pol. 2005;52(2):485-91. Epub 2005 May 15.

The effect of forskolin was augmented by cycloheximide, suggesting that an inhibitory protein, whose synthesis was inhibited by cycloheximide, could be involved in negative regulation of SF-1 expression.
6(0,0,0,6) Details
16469813 Huang YH, Lee CY, Tai PJ, Yen CC, Liao CY, Chen WJ, Liao CJ, Cheng WL, Chen RN, Wu SM, Wang CS, Lin KH: Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones. Endocrinology. 2006 May;147(5):2481-9. Epub 2006 Feb 9.

Cycloheximide inhibited T (3)-induced SULT2A1 expression, suggesting that regulation was indirect.
SULT2A1 has been reported to be regulated by the two transcription factors, steroidogenic factor 1 (SF1) and GATA, in the human adrenal gland.
1(0,0,0,1) Details