Protein Information

Name CCL26
Synonyms CC chemokine IMAC; TSC1; CCL26; Eotaxin 3; IMAC; MIP 4 alpha; MIP 4a; MIP 4alpha…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
15863444 Abonyo BO, Alexander MS, Heiman AS: Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L478-88. Epub 2005 Apr 29.

Cycloheximide and actinomycin D abrogated IL-4- and IL-13-dependent CCL26 but not CCL24 secretion.
10(0,0,0,10) Details
16084752 Blanchard C, Durual S, Estienne M, Emami S, Vasseur S, Cuber JC: Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6. Int J Biochem Cell Biol. 2005 Dec;37(12):2559-73. Epub 2005 Jul 21.

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16464865 Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL: TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006 Mar 31;281(13):8313-6. Epub 2006 Feb 7.

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16264039 Tsuji K, Yamamoto S, Ou W, Nishi N, Kobayashi I, Zaitsu M, Muro E, Sadakane Y, Ichimaru T, Hamasaki Y: dsRNA enhances eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells. Eur Respir J. 2005 Nov;26(5):795-803.

Poly (IC)-induced upregulation of IL-4Ralpha was inhibited by treatment with cycloheximide or dexamethasone.
5(0,0,0,5) Details
18030348 Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jeno P, Arrieumerlou C, Hall MN: PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One. 2007 Nov 21;2(11):e1217.

Hyperactivation of mTOR by TSC1/2 knock down enhanced apoptosis whereas PRR5L knock down reduced apoptosis.
HeLa cells in which PRAS40 was knocked down were protected against induction of apoptosis by TNFalpha and cycloheximide.
1(0,0,0,1) Details