Protein Information

Name Regucalcin
Synonyms RC; RGN; Regucalcin; SMP 30; SMP30; Senescence marker protein 30; regucalcin (senescence marker protein 30); Regucalcins…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18327666 Yamaguchi M, Goto M, Uchiyama S, Nakagawa T: Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions. Mol Cell Biochem. 2008 May;312(1-2):157-66. Epub 2008 Mar 9.

The stimulatory effects of zinc sulfate on Runx2, OPG, or regucalcin mRNAs were significantly prevented in the presence of cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole (10 (-6) M), an inhibitor of transcription activity.
35(0,1,1,5) Details
16820941 Otomo Y, Yamaguchi M: Regulatory effect of exogenous regucalcin on cell function in osteoblastic MC3T3-E1 cells: involvement of intracellular signaling factor. Int J Mol Med. 2006 Aug;18(2):321-7.

The presence of regucalcin did not have a significant effect on protein and DNA contents in the cells cultured with cycloheximide (10 (-7) M), an inhibitor of protein synthesis, or 5,6-dichloro -1-beta-D-ribofuranosylbenzimidazole (10 (-6) M), an inhibitor of transcription activity; which each inhibitor caused a significant decrease in those contents.
10(0,0,0,10) Details
15578574 Yamaguchi M, Uchiyama S: Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures. J Cell Biochem. 2005 Mar 1;94(4):794-803.

The effect of regucalcin on osteoclast-like cell formation was not significantly blocked in the presence of cycloheximide, an inhibitor of protein synthesis, or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), an inhibitor of transcriptional activity.
9(0,0,0,9) Details