| Name | GTPase |
|---|---|
| Synonyms | RAC3; RAC3; Ras related C3 botulinum substrate 3; Ras related C3 botulinum toxin substrate 3; p21 Rac3; Ras related C3 botulinum substrate 3s; Ras related C3 botulinum toxin substrate 3s; p21 Rac3s… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15545276 | Park JI, Collinson EJ, Grant CM, Dawes IW: Rom2p, the Rho1 GTP/GDP exchange factor of Saccharomyces cerevisiae, can mediate stress responses via the Ras-cAMP pathway. J Biol Chem. 2005 Jan 28;280(4):2529-35. Epub 2004 Nov 15. ROM2 was isolated as a suppresser of heat and NaCl sensitivity caused by the lack of the Ras-GTPase activator Ira2p or of cAMP phosphodiesterases. Subsequent analysis of strains with a rom2 deletion showed that Rom2p is essential for resistance to a variety of stresses caused by freeze-thawing, oxidants, cycloheximide, NaCl, or ions. |
1(0,0,0,1) | Details |
| 19748353 | Binda M, Peli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C: The Vam6 GEF controls TORC1 by activating the EGO complex. . Mol Cell. 2009 Sep 11;35(5):563-73. Here, we report that the yeast Rag GTPase homolog Gtr1, a component of the vacuolar-membrane-associated EGO complex (EGOC), interacts with and activates TORC1 in an amino-acid-sensitive manner. |
1(0,0,0,1) | Details |
| 17405813 | Neel NF, Lapierre LA, Goldenring JR, Richmond A: RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci. 2007 May 1;120(Pt 9):1559-71. Epub 2007 Apr 3. We conclude that oscillation of RhoB GTPase activity is essential for appropriate sorting decisions, and for directing CXCR2 degradation and recycling--events that are required for optimal chemotaxis. |
1(0,0,0,1) | Details |
| 16734383 | Dunford JE, Rogers MJ, Ebetino FH, Phipps RJ, Coxon FP: Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases. J Bone Miner Res. 2006 May;21(5):684-94. The Rac-GTP that increased after N-BP treatment was newly translated, cytoplasmic unprenylated protein, because it was not labeled with [(14) C] and the increase in Rac-GTP was prevented by cycloheximide. RESULTS: Rather than inhibiting GTPase function, loss of prenylation after treatment with N-BPs caused an increase in the GTP-bound form of Rac, Cdc42, and Rho in J774 cells and osteoclast-like cells, which paralleled the rate of accumulation of unprenylated small GTPases. |
1(0,0,0,1) | Details |
| 15629464 | Park JI, Grant CM, Dawes IW: The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. Biochem Biophys Res Commun. 2005 Feb 4;327(1):311-9. Here, we isolated IRA2, encoding the Ras GTPase activator, as a global stress response gene. Deletion of PDE2, similar to ira2 deletion, rendered cells sensitive to freeze-thawing, peroxides, paraquat, cycloheximide, heavy metals, NaCl, heat, or cold shock. |
1(0,0,0,1) | Details |
| 15531589 | Gerhard R, Tatge H, Genth H, Thum T, Borlak J, Fritz G, Just I: Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB. J Biol Chem. 2005 Jan 14;280(2):1499-505. Epub 2004 Nov 5. The up-regulation of RhoB was approximately 15-fold and was based on the de novo synthesis of the GTPase because cycloheximide completely inhibited the toxin A effect. |
31(0,1,1,1) | Details |
| 15664648 | Jeffress M, Fields S: Identification of putative Plasmodium falciparum mefloquine resistance genes. Mol Biochem Parasitol. 2005 Feb;139(2):133-9. PFI0195c, which likely encodes a small GTPase activator (GAP), also conferred resistance to cycloheximide and halofantrine in yeast. |
31(0,1,1,1) | Details |
| 16148026 | Mzali R, Seguin L, Liot C, Auger A, Pacaud P, Loirand G, Thibault C, Pierre J, Bertoglio J: Regulation of Rho signaling pathways in interleukin-2-stimulated human T-lymphocytes. FASEB J. 2005 Nov;19(13):1911-3. Epub 2005 Sep 7. In addition, it has recently been recognized that Rho GTPase activity is required for development of the immune system, as well as for the specialized functions of the peripheral cells that act in the immune response such as antigen presenting cells and lymphocytes. |
4(0,0,0,4) | Details |
| 16431369 | Forster R, Weiss M, Zimmermann T, Reynaud EG, Verissimo F, Stephens DJ, Pepperkok R: Secretory cargo regulates the turnover of COPII subunits at single ER exit sites. Curr Biol. 2006 Jan 24;16(2):173-9. It consists of the Sar1p GTPase and the Sec23/24p and the Sec13/31p subcomplexes . |
2(0,0,0,2) | Details |
| 15808886 | Xu JW, Ikeda K, Kobayakawa A, Ikami T, Kayano Y, Mitani T, Yamori Y: Downregulation of Rac1 activation by in aortic smooth muscle cells. Life Sci. 2005 Apr 29;76(24):2861-72. In this study, we investigated whether regulates Rac1 GTPase activity, a partner of oxidase. On the other hand, co-incubation with caffei caid and cycloheximide significantly accelerated the Rac1 degradation. |
2(0,0,0,2) | Details |
| 19798499 | Lehr NA, Adomas A, Asiegbu FO, Hampp R, Tarkka MT: WS-5995 B, an antifungal agent inducing differential gene expression in the conifer pathogen Heterobasidion annosum but not in Heterobasidion abietinum. Appl Microbiol Biotechnol. 2009 Nov;85(2):347-58. Epub 2009 Oct 2. Differences in antibiotic sensitivity between two isolates belonging to two species, H. annosum 005 and H. abietinum 331, were investigated by comparative gene expression analysis using macroarrays and quantitative RT-PCR after WS-5995 B, structurally related mollisin and unrelated cycloheximide application. Treatment with 25 microM WS-5995 B for 2 h resulted in a significant up-regulation of expression of -monophosphate dehydrogenase, phosphoglucomutase and GTPase genes, while the expression of genes encoding for thioredoxin and glutathione dependent formaldehyde dehydrogenase was down-regulated in the sensitive fungal strain. |
1(0,0,0,1) | Details |
| 16464865 | Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL: TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006 Mar 31;281(13):8313-6. Epub 2006 Feb 7. TSC1 is known to stabilize TSC2 by forming a complex with TSC2, which is a GTPase-activating protein for the Rheb small GTPase. |
1(0,0,0,1) | Details |
| 17310067 | Cottrell GS, Padilla B, Pikios S, Roosterman D, Steinhoff M, Grady EF, Bunnett NW: Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. J Biol Chem. 2007 Apr 20;282(16):12260-71. Epub 2007 Feb 19. Cycloheximide did not affect resensitization, but bafilomycin A (1), an inhibitor of vacuolar H (+)-ATPases, abolished resensitization. Recycling CLR and RAMP1 were detected in endosomes containing Rab4a and Rab11a, and expression of GTPase-defective Rab4aS22N and Rab11aS25N inhibited resensitization. |
1(0,0,0,1) | Details |
| 15569826 | Furst R, Brueckl C, Kuebler WM, Zahler S, Krotz F, Gorlach A, Vollmar AM, Kiemer AK: Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD (P) H oxidase/Nox2-activation. Circ Res. 2005 Jan 7;96(1):43-53. Epub 2004 Nov 29. Pull-down assays and confocal microscopy showed that ANP activates the small Rho-GTPase Rac1. |
1(0,0,0,1) | Details |
| 15772076 | Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG: The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16. TSC2 contains a GTPase-activator domain that promotes hydrolysis of GTP bound to Rheb, which positively regulates mTOR signaling. |
1(0,0,0,1) | Details |
| 17474905 | Sheahan KL, Satchell KJ: Inactivation of small Rho GTPases by the multifunctional RTX toxin from Vibrio cholerae. Cell Microbiol. 2007 May;9(5):1324-35. Inactivation of Rho by RTX was reversible in the presence of cycloheximide and by treatment of cells with CNF1 to constitutively activate Rho. These data suggest that RTX targets Rho GTPase regulation rather than affecting Rho GTPase directly. |
1(0,0,0,1) | Details |
| 17158932 | Li C, Wu RC, Amazit L, Tsai SY, Tsai MJ, O'Malley BW: Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover. Mol Cell Biol. 2007 Feb;27(4):1296-308. Epub 2006 Dec 11. SRC-3/AIB1/ACTR/pCIP/RAC3/TRAM-1 is a primary transcriptional coactivator for the estrogen receptor. SRC-3 shows a time-dependent decay in the presence of cycloheximide which is not apparent for the cytoplasmic mutant. |
1(0,0,0,1) | Details |