Protein Information

Name FOXO1
Synonyms FKH 1; FKH1; FKHR; FOXO 1; FOXO1; FOXO1A; Forkhead box O1A; Forkhead box protein O1A…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18335505 Mercado GE, Xia SJ, Zhang C, Ahn EH, Gustafson DM, Lae M, Ladanyi M, Barr FG: Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target. Genes Chromosomes Cancer. 2008 Jun;47(6):510-20.

The findings of cycloheximide inhibition and time-course studies are consistent with the hypothesis that the PAX3-FKHR protein acts directly on the MYCN gene at the transcriptional level.
88(1,1,1,8) Details
17482685 Nowak K, Killmer K, Gessner C, Lutz W: E2F-1 regulates expression of FOXO1 and FOXO3a. . Biochim Biophys Acta. 2007 Apr;1769(4):244-52. Epub 2007 Apr 6.

Indeed, a 4-hydroxytamoxifen activated E2F-1-ER fusion protein induced FOXO expression in the presence of cycloheximide.
3(0,0,0,3) Details