| Name | P27 |
|---|---|
| Synonyms | FAM14D; p27; IFI27; ISG12; ISG12(a) protein; Interferon alpha induced 11.5 kDa protein; Interferon alpha inducible protein 27; ISG12(a) proteins… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17407140 | Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, Wang L, Sun L, Jin J, Yang Y, Zha X: Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem. 2007 Oct 15;102(3):704-18. Cycloheximide (Chx) treatment and pulse-chase experiments revealed that overexpression of integrin beta1 prolonged the half-life of p27 (Kip1) by inhibiting its degradation. |
37(0,1,1,7) | Details |
| 17938263 | Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R: p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol Cancer Ther. 2007 Oct;6(10):2696-707. Next, studies were done to examine mechanisms of their induction where cycloheximide-chase experiments showed that silibinin increases p21 and p27 protein half-life. |
11(0,0,1,6) | Details |
| 19424645 | Lee EY, Jeon MJ, Yang W, Shin I: Effect of p27 on motility of MDA-MB-231 breast cancer cells. Oncol Rep. 2009 Jun;21(6):1621-5. Wound healing assays revealed that migration of MDA-MB-231 hpshRNA cells was markedly impaired compared to MDA-MB-231 mpshRNA cells, especially when cycloheximide was added to block protein synthesis. |
7(0,0,0,7) | Details |
| 17475922 | Egozi D, Shapira M, Paor G, Ben-Izhak O, Skorecki K, Hershko DD: Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells. FASEB J. 2007 Sep;21(11):2807-17. Epub 2007 May 2. |
7(0,0,0,7) | Details |
| 19591933 | Mishra A, Godavarthi SK, Jana NR: UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27. Neurobiol Dis. 2009 Oct;36(1):26-34. Epub 2009 Jul 8. |
5(0,0,0,5) | Details |
| 16407831 | Taube ME, Liu XW, Fridman R, Kim HR: TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27 (KIP1) protein. Oncogene. 2006 May 18;25(21):3041-8. |
4(0,0,0,4) | Details |
| 16859513 | Shapira M, Kakiashvili E, Rosenberg T, Hershko DD: The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells. Breast Cancer Res. 2006;8(4):R46. The decrease in p27 levels is mainly the result of enhanced proteasome-dependent degradation mediated by its specific ubiquitin ligase subunit S phase kinase protein 2 (Skp2). The effect of rapamycin on the degradation rate of Skp2 expression was examined in cycloheximide-treated cells and in relationship to the anaphase promoting complex/Cdh1 (APC\C) inhibitor Emi1. |
3(0,0,0,3) | Details |
| 19602254 | Bangiyeva V, Rosenbloom A, Alexander AE, Isanova B, Popko T, Schoenfeld AR: Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer. 2009 Jul 14;9:229. RESULTS: As a whole, type 1 mutants varied greatly from type 2 mutants, demonstrating high levels of HIF-2alpha, cyclin D1 and alpha5 integrin, lower p27 levels, and a spindly, fibroblastic cellular appearance. |
2(0,0,0,2) | Details |
| 19009649 | Guller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, Daniel F: c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World J Gastroenterol. 2008 Nov 7;14(41):6339-46. The levels of cell cycle regulatory proteins (Cyclin D1, E, A) cyclin dependent kinases (cdk) cdk2, cdk4, cdk6, and their inhibitors p15, p16, p21, p27, total and phosphorylated GSK-3beta and epidermal growth factor receptor (EGF-R) were assayed by Western blotting. Stability of Cyclin D1 was studied by cycloheximide blockade experiments. |
1(0,0,0,1) | Details |
| 17338678 | Shenkman M, Tolchinsky S, Kondratyev M, Lederkremer GZ: Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response. Biochem J. 2007 Jun 15;404(3):509-16. Stabilization of p27 through this mechanism may explain the cell cycle arrest in G1 when translation is blocked by inhibitors or by the UPR. |
1(0,0,0,1) | Details |
| 15964852 | Zhu H, Nie L, Maki CG: Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif. J Biol Chem. 2005 Aug 12;280(32):29282-8. Epub 2005 Jun 17. p21 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors that includes p21, p27, and p57. |
1(0,0,0,1) | Details |
| 16206267 | Lovborg H, Oberg F, Rickardson L, Gullbo J, Nygren P, Larsson R: Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram. Int J Cancer. 2006 Mar 15;118(6):1577-80. Disulfiram was also able to induce accumulation of p27 (Kip1) and to prolong the half-life of c-Myc, both targets for proteasome-dependent degradation. |
1(0,0,0,1) | Details |
| 17989348 | Papineni S, Chintharlapalli S, Safe S: Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Mol Pharmacol. 2008 Feb;73(2):553-65. Epub 2007 Nov 7. In contrast, beta-CDODA-Me also decreased androgen receptor (AR) and prostate-specific antigen (PSA) mRNA and protein levels through kinase-independent pathways. beta-CDODA-Me repressed AR mRNA transcription, whereas decreased PSA mRNA levels were dependent on protein synthesis and were reversed by cycloheximide. |
0(0,0,0,0) | Details |
| 16894473 | Fu Y, Wang LY, Liang YL, Jin JW, Fang ZY, Zha XL: Integrin beta (1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721. Acta Biochim Biophys Sin. 2006 Aug;38(8):523-30. Cycloheximide treatment experiment revealed that the half-life of p27 protein was prolonged in integrin beta1A overexpressing cells, indicating that integrin beta (1A) inhibited the degradation of p27 protein. |
85(1,1,1,5) | Details |
| 16879986 | Godbole D, Mojamdar M, Pal JK: Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of biosynthesis. Cell Biol Int. 2006 Nov;30(11):895-902. Epub 2006 Jun 30. On exposure to cycloheximide, increased Tyr degradation was seen in amelanotic cells, as indicated by increased co-localization of p27 and Tyr. |
85(1,1,1,5) | Details |