| Name | cyclin D1 |
|---|---|
| Synonyms | B cell CLL/lymphoma 1; B cell leukemia 1; BCL 1; BCL 1 oncogene; BCL1; CCND 1; CCND1; Cyclin D1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19412536 | Robert F, Carrier M, Rawe S, Chen S, Lowe S, Pelletier J: Altering chemosensitivity by modulating translation elongation. PLoS One. 2009;4(5):e5428. Epub 2009 May 1. METHODOLOGY/PRINCIPAL FINDINGS: Here, we chose four structurally different chemical inhibitors of translation elongation: homoharringtonine, bruceantin, didemnin B and cycloheximide, and tested their ability to alter the chemoresistance of Emu-myc lymphomas harbouring lesions in Pten, Tsc2, Bcl-2, or eIF4E. We attribute this effect to a reduction in levels of pro-oncogenic or pro-survival proteins having short half-lives, like Mcl-1, cyclin D1 or c-Myc. |
1(0,0,0,1) | Details |
| 16180102 | Jiang Y, Cheng DW, Crook ED, Singh LP: Transforming growth factor-beta1 regulation of laminin gamma1 and fibronectin expression and survival of mouse mesangial cells. Mol Cell Biochem. 2005 Oct;278(1-2):165-75. TGF-beta1 elevates pro-apoptotic caspase-3 activity and decrease cell cycle progression factor cyclin D1 expression, which parallels cell death. |
1(0,0,0,1) | Details |
| 18337562 | Murooka TT, Rahbar R, Platanias LC, Fish EN: CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1. Blood. 2008 May 15;111(10):4892-901. Epub 2008 Mar 12. Notably, CCL5 induced protein translation of cyclin D1 and MMP-9, known mediators of migration. Cycloheximide, but not actinomycin D, significantly reduced chemotaxis, suggesting a possible role for mRNA translation in T-cell migration. |
1(0,0,0,1) | Details |
| 19168569 | Andrew AS, Mason RA, Memoli V, Duell EJ: Arsenic activates EGFR pathway signaling in the lung. . Toxicol Sci. 2009 Jun;109(2):350-7. Epub 2009 Jan 23. Downstream of EGFR, arsenic exposure increased pERK and cyclin D1 levels. |
1(0,0,0,1) | Details |
| 19602254 | Bangiyeva V, Rosenbloom A, Alexander AE, Isanova B, Popko T, Schoenfeld AR: Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer. 2009 Jul 14;9:229. RESULTS: As a whole, type 1 mutants varied greatly from type 2 mutants, demonstrating high levels of HIF-2alpha, cyclin D1 and alpha5 integrin, lower p27 levels, and a spindly, fibroblastic cellular appearance. |
1(0,0,0,1) | Details |
| 15825190 | Suzuki M, Koike T: Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of -induced neuronal death. J Neurosci Res. 2005 May 15;80(4):549-61. A robust induction of c-jun and cyclin D1 occurred following treatment with PDP-Q22-NLS. |
1(0,0,0,1) | Details |
| 15870696 | Reid G, Metivier R, Lin CY, Denger S, Ibberson D, Ivacevic T, Brand H, Benes V, Liu ET, Gannon F: Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by and trichostatin A. Oncogene. 2005 Jul 21;24(31):4894-907. Concomitant treatment with cycloheximide prevented most of these changes in gene expression, including downregulation of ERalpha mRNA, indicating that a limited number of genes signal a hyperacetylated state within cells. |
0(0,0,0,0) | Details |
| 17989348 | Papineni S, Chintharlapalli S, Safe S: Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Mol Pharmacol. 2008 Feb;73(2):553-65. Epub 2007 Nov 7. In contrast, beta-CDODA-Me also decreased androgen receptor (AR) and prostate-specific antigen (PSA) mRNA and protein levels through kinase-independent pathways. beta-CDODA-Me repressed AR mRNA transcription, whereas decreased PSA mRNA levels were dependent on protein synthesis and were reversed by cycloheximide. |
0(0,0,0,0) | Details |
| 19009649 | Guller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, Daniel F: c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. World J Gastroenterol. 2008 Nov 7;14(41):6339-46. Stability of Cyclin D1 was studied by cycloheximide blockade experiments. |
38(0,1,1,8) | Details |
| 19074853 | Feng Q, Sekula D, Guo Y, Liu X, Black CC, Galimberti F, Shah SJ, Sempere LF, Memoli V, Andersen JB, Hassel BA, Dragnev K, Dmitrovsky E: UBE1L causes lung cancer growth suppression by targeting cyclin D1. . Mol Cancer Ther. 2008 Dec;7(12):3780-8. Cycloheximide treatment augmented this cyclin D1 protein instability. |
16(0,0,1,11) | Details |
| 17310991 | Feng Q, Sekula D, Muller R, Freemantle SJ, Dmitrovsky E: Uncovering residues that regulate cyclin D1 proteasomal degradation. . Oncogene. 2007 Aug 2;26(35):5098-106. Epub 2007 Feb 19. Eighteen lysines in cyclin D1 had single, double or multiple mutations engineered before transfection into BEAS-2B human bronchial epithelial (HBE) cells to evaluate stabilities after (RA) or cycloheximide treatments. |
15(0,0,1,10) | Details |
| 16503970 | Alao JP, Gamble SC, Stavropoulou AV, Pomeranz KM, Lam EW, Coombes RC, Vigushin DM: The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines. Mol Cancer. 2006 Feb 17;5:7. |
10(0,0,0,10) | Details |
| 15870875 | Kwon YK, Jun JM, Shin SW, Cho JW, Suh SI: decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells. Int J Oncol. 2005 Jun;26(6):1597-603. |
8(0,0,0,8) | Details |
| 19071090 | Choo DW, Baek HJ, Motoyama N, Cho KH, Kim HS, Kim SS: ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiation. Biochem Biophys Res Commun. 2009 Jan 23;378(4):847-50. Epub 2008 Dec 9. |
7(0,0,0,7) | Details |
| 17329956 | Matsumoto E, Hatanaka M, Bohgaki M, Maeda S: PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13--induced differentiation of myeloleukemia cells. Kobe J Med Sci. 2006;52(6):181-94. |
6(0,0,0,6) | Details |
| 17606477 | MacManus CF, Pettigrew J, Seaton A, Wilson C, Maxwell PJ, Berlingeri S, Purcell C, McGurk M, Johnston PG, Waugh DJ: Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol Cancer Res. 2007 Jul;5(7):737-48. Epub 2007 Jul 2. We have shown previously that interleukin-8 (IL-8) and IL-8 receptor expression is elevated in tumor cells of human prostate biopsy tissue and correlates with increased cyclin D1 expression. Administration of recombinant human IL-8 induced a rapid, time-dependent increase in cyclin D1 expression in AIPC cells, a response attenuated by the translation inhibitor cycloheximide but not by the RNA synthesis inhibitor, actinomycin D. |
5(0,0,0,5) | Details |
| 17404514 | Simpson PJ, Moon C, Kleman AM, Connolly E, Ronnett GV: Progressive and inhibitory cell cycle proteins act simultaneously to regulate neurotrophin-mediated proliferation and maturation of neuronal precursors. Cell Cycle. 2007 May 2;6(9):1077-89. Epub 2007 May 7. Both NGF and BDNF increase the expression of cyclin D1 and cyclin-dependent kinase 4 (cdk4), with temporal expression patterns that parallel the proliferation kinetics of their cellular targets. |
4(0,0,0,4) | Details |
| 18157634 | Mikheev AM, Mikheeva SA, Maxwell JP, Rivo JV, Rostomily R, Swisshelm K, Zarbl H: Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. Breast Cancer Res Treat. 2008 Nov;112(2):263-73. Epub 2007 Dec 22. Consistent with the results of these transient transfection assays, we were unable to demonstrate the expected beta-catenin dependent, TCF/Lef mediated inhibition of cyclin D1 and c-myc gene transcription in breast cells overexpressing DKK-1. |
1(0,0,0,1) | Details |