| Name | integrins |
|---|---|
| Synonyms | Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16051604 | Chen FH, Thomas AO, Hecht JT, Goldring MB, Lawler J: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem. 2005 Sep 23;280(38):32655-61. Epub 2005 Jul 28. |
7(0,0,0,7) | Details |
| 16236823 | Vainionpaa N, Kikkawa Y, Lounatmaa K, Miner JH, Rousselle P, Virtanen I: Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am J Physiol Cell Physiol. 2006 Mar;290(3):C764-75. Epub 2005 Oct 19. When the protein synthesis during the adhesion was inhibited with cycloheximide, the formation of fibrillar adhesions on laminin-10 was abolished, suggesting that laminin-10 does not stimulate the formation of any adhesion structures. Quantitative cell adhesion assays showed that in the endothelial cell adhesion to laminin-10, Lu acted in concert with integrins beta (1) and alpha (v) beta (3), whereas in the adhesion to laminin-10/11, Lu and integrin beta (1) were involved. |
3(0,0,0,3) | Details |
| 16669788 | Bhattacharya S, Ray RM, Johnson LR: Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J. 2006 Aug 1;397(3):437-47. Arg-Gly-Asp-Ser inhibited beta3, Src and Akt phosphorylation and sensitized polyamine-depleted cells to tumour necrosis factor alpha/cycloheximide-mediated apoptosis. |
3(0,0,0,3) | Details |
| 17825525 | Ray RM, Bhattacharya S, Johnson LR: EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cell Signal. 2007 Dec;19(12):2519-27. Epub 2007 Aug 15. We have previously shown that DFMO leads to the inhibition of de novo polyamine synthesis, which in turn rapidly activates Src, STAT3 and NF-kappaB via integrin beta3 in intestinal epithelial cells. |
3(0,0,0,3) | Details |
| 16817231 | Siri S, Chen MJ, Chen TT: Biological activity of rainbow trout Ea4-peptide of the pro-insulin-like growth factor (pro-IGF)-I on promoting attachment of breast cancer cells (MDA-MB-231) via alpha2- and beta1-integrin. J Cell Biochem. 2006 Dec 15;99(6):1524-35. Blocking new protein synthesis by cycloheximide significantly reduced the attachment of MDA-MB-231 cells to rtEa4-peptide coated wells by 50%. |
3(0,0,0,3) | Details |
| 15678124 | Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, Doyle K, Lessov NS, Simon RP, Stenzel-Poore MP: Neuroprotection by osteopontin in stroke. . J Cereb Blood Flow Metab. 2005 Feb;25(2):217-25. The effect of OPN depends on the Arg-Gly-Asp (RGD)-containing motif as the protective effect of OPN in vitro was blocked by an RGD-containing hexapeptide, which prevents integrin receptors binding to their ligands. The protective effect of OPN was also blocked by the protein synthesis inhibitor cycloheximide, suggesting that the neuroprotective effect of OPN required new protein synthesis. |
1(0,0,0,1) | Details |
| 15735708 | Rodrigue CM, Porteu F, Navarro N, Bruyneel E, Bracke M, Romeo PH, Gespach C, Garel MC: The cancer chemopreventive agent induces tensin, a cell-matrix adhesion protein with signaling and antitumor activities. Oncogene. 2005 May 5;24(20):3274-84. Tensin, a cell-matrix adhesion protein binding the integrins and cytoskeletal actin filaments also interacts with PI3-kinase and JNK signaling pathways. |
1(0,0,0,1) | Details |
| 19602254 | Bangiyeva V, Rosenbloom A, Alexander AE, Isanova B, Popko T, Schoenfeld AR: Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer. 2009 Jul 14;9:229. RESULTS: As a whole, type 1 mutants varied greatly from type 2 mutants, demonstrating high levels of HIF-2alpha, cyclin D1 and alpha5 integrin, lower p27 levels, and a spindly, fibroblastic cellular appearance. |
1(0,0,0,1) | Details |
| 15633612 | Yang S, Yip R, Polena S, Sharma M, Rao S, Griciene P, Gintautas J, Jerome H: Reactive species increased focal adhesion kinase production in pulmonary microvascular endothelial cells. Proc West Pharmacol Soc. 2004;47:54-6. FAK is regulated by integrin-dependent cell adhesion and can control phosphorylation of downstream substrates, like paxillin. We found that low dose H2O2 induced increased FAK production in pulmonary microvascular endothelial cells, which could be blocked by cycloheximide (CHX), a protein synthesis inhibitor. |
1(0,0,0,1) | Details |
| 17914591 | Pook SH, Rahmat JN, Esuvaranathan K, Mahendran R: Internalization of Mycobacterium bovis, Bacillus Calmette Guerin, by bladder cancer cells is cytotoxic. Oncol Rep. 2007 Nov;18(5):1315-20. Transfection of the alpha5 integrin gene into the BCG unresponsive bladder cancer cell line, RT4, caused an increase in bacterial uptake and also increased cell death. Treatment of cells with cycloheximide did not prevent bacterial internalization but blocked its cytotoxic effect suggesting that unlike cell death, the process of bacterial internalization does not require new protein synthesis. |
1(0,0,0,1) | Details |
| 16728660 | von Wnuck Lipinski K, Keul P, Ferri N, Lucke S, Heusch G, Fischer JW, Levkau B: Integrin-mediated transcriptional activation of inhibitor of apoptosis proteins protects smooth muscle cells against apoptosis induced by degraded collagen. Circ Res. 2006 Jun 23;98(12):1490-7. Epub 2006 May 25. |
1(0,0,0,1) | Details |
| 19539609 | Hivert V, Pierre J, Raingeaud J: Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation. Biochem Pharmacol. 2009 Oct 15;78(8):1017-25. Epub 2009 Jun 17. HEF1 is present at focal adhesions and is involved in integrin signalling mediating cytoskeleton reorganization associated with cell migration, adhesion or apoptosis. |
1(0,0,0,1) | Details |
| 15753078 | Arbel-Goren R, Levy Y, Ronen D, Zick Y: Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. J Biol Chem. 2005 May 13;280(19):19105-14. Epub 2005 Mar 7. Galectin-8, a mammalian beta-galactoside binding lectin, functions as an extracellular matrix protein that forms high affinity interactions with integrins. When p21 expression was inhibited by cycloheximide, galectin-8 directed the cells toward apoptosis, which involves induction of poly (ADP- polymerase cleavage. |
1(0,0,0,1) | Details |
| 15801978 | Shirk AJ, Kuver R: Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells. BMC Gastroenterol. 2005 Mar 31;5:12. We hypothesized that EGF receptor and integrin signalling pathways interact in mediating cellular adhesion and invasion in pancreatic cancer, and that invasiveness correlates temporally with detachment from extracellular matrix. The loss of adhesion was reversed by AG825, an inhibitor of erbB2 receptor signalling and by wortmannin, a PI3K inhibitor, but not by the protein synthesis inhibitor cycloheximide. |
1(0,0,0,1) | Details |
| 18448534 | Harwood LJ, Gerber H, Sobrino F, Summerfield A, McCullough KC: Dendritic cell internalization of foot-and-mouth disease virus: influence of binding on virus uptake and induction of the immune response. J Virol. 2008 Jul;82(13):6379-94. Epub 2008 Apr 30. Although it is clear that FMDV enters epithelial cells via integrins, little is known about FMDV interaction with DC. The HS-binding FMDV replicated in DC, albeit transiently, which was demonstrable by its sensitivity to cycloheximide treatment and the short duration of infectious virus production. |
1(0,0,0,1) | Details |
| 17407140 | Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, Wang L, Sun L, Jin J, Yang Y, Zha X: Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem. 2007 Oct 15;102(3):704-18. Cycloheximide (Chx) treatment and pulse-chase experiments revealed that overexpression of integrin beta1 prolonged the half-life of p27 (Kip1) by inhibiting its degradation. |
40(0,1,1,10) | Details |
| 15535971 | Kamiya S, Kawaguchi T, Hasebe S, Kamiya N, Saito Y, Miura S, Wada S, Yajima H, Katayama T, Fukai F: A fibronectin fragment induces tumor necrosis factor production of rat basophilic leukemia cells. Biochim Biophys Acta. 2004 Nov 18;1675(1-3):87-94. The TNF-alpha secretion was abrogated by treatment of RBL-2H3 cells with cycloheximide, indicating the de novo synthesis of TNF-alpha, but not with polymyxin B, excluding the possible TNF-alpha induction by some contaminated lipopolysaccharides. A 22-mer synthetic peptide originated from the Hep 2 domain, termed FNIII14, which has been found to negatively modulate the beta1 integrin activation, had the ability to induce TNF-alpha production, whereas this activity of FNIII14 disappeared by shuffling a YTIYVIAL sequence essential for the integrin-inactivating activity. |
1(0,0,0,1) | Details |
| 15563689 | Zhou X, Gao XP, Fan J, Liu Q, Anwar KN, Frey RS, Malik AB: LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L655-62. Epub 2004 Nov 24. We identify herein a novel signaling function of the Toll-like receptor-4 (TLR4), the lipopolysaccharide (LPS) receptor mediating the innate immune response, in inducing the expression of CD11b/CD18 integrin in polymorphonuclear leukocytes (PMNs). TLR4-activated CD11b expression was cycloheximide sensitive and involved the activation of transcription factors, NF-kappaB and c-Jun/PU.1. |
1(0,0,0,1) | Details |
| 16894473 | Fu Y, Wang LY, Liang YL, Jin JW, Fang ZY, Zha XL: Integrin beta (1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721. Acta Biochim Biophys Sin. 2006 Aug;38(8):523-30. Cycloheximide treatment experiment revealed that the half-life of p27 protein was prolonged in integrin beta1A overexpressing cells, indicating that integrin beta (1A) inhibited the degradation of p27 protein. |
38(0,1,1,8) | Details |
| 16282198 | Chao JT, Martinez-Lemus LA, Kaufman SJ, Meininger GA, Ramos KS, Wilson E: Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2006 Apr;290(4):C972-80. Epub 2005 Nov 9. Actinomycin D and cycloheximide attenuated PDGF-induced increases in alpha (7)-integrin, indicating the involvement of de novo mRNA and protein synthesis. |
13(0,0,1,8) | Details |