| Name | c Myc |
|---|---|
| Synonyms | MYC; Myc proto oncogene protein; Oncogene MYC; Transcription factor p64; c Myc; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); Myc proto oncogene proteins… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16206267 | Lovborg H, Oberg F, Rickardson L, Gullbo J, Nygren P, Larsson R: Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram. Int J Cancer. 2006 Mar 15;118(6):1577-80. Disulfiram was also able to induce accumulation of p27 (Kip1) and to prolong the half-life of c-Myc, both targets for proteasome-dependent degradation. |
1(0,0,0,1) | Details |
| 19412536 | Robert F, Carrier M, Rawe S, Chen S, Lowe S, Pelletier J: Altering chemosensitivity by modulating translation elongation. PLoS One. 2009;4(5):e5428. Epub 2009 May 1. METHODOLOGY/PRINCIPAL FINDINGS: Here, we chose four structurally different chemical inhibitors of translation elongation: homoharringtonine, bruceantin, didemnin B and cycloheximide, and tested their ability to alter the chemoresistance of Emu-myc lymphomas harbouring lesions in Pten, Tsc2, Bcl-2, or eIF4E. We attribute this effect to a reduction in levels of pro-oncogenic or pro-survival proteins having short half-lives, like Mcl-1, cyclin D1 or c-Myc. |
1(0,0,0,1) | Details |
| 17974960 | Zhang L, Wali A, Ramana CV, Rishi AK: Cell growth inhibition by okadaic acid involves gut-enriched Kruppel-like factor mediated enhanced expression of c-Myc. Cancer Res. 2007 Nov 1;67(21):10198-206. Here, we investigated whether induction of c-Myc by OA or protein synthesis inhibitor cycloheximide contributed to HBC growth inhibition and the mechanisms involved. |
125(1,2,3,10) | Details |
| 15791453 | Murakami J, Asaumi J, Kawai N, Tsujigiwa H, Yanagi Y, Nagatsuka H, Inoue T, Kokeguchi S, Kawasaki S, Kuroda M, Tanaka N, Matsubara N, Kishi K: Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer. Cancer Chemother Pharmacol. 2005 Jul;56(1):22-8. Epub 2005 Mar 25. Moreover, cotreatment of protein synthesis inhibitor cycloheximide (CHX) resulted in the induction of hTERT transcription by FR901228. We further examined the effect of FR901228 on c-myc protein, which is one of the main hTERT transcription activators. |
3(0,0,0,3) | Details |
| 18455888 | Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L: Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region. Gene. 2008 Jul 1;417(1-2):5-12. Epub 2008 Mar 12. However, the presence of the protein synthesis inhibitor cycloheximide could reverse the repression of Myc, indicating the indirect repression of human NDRG1 by Myc. The data revealed that both N-Myc and c-Myc can repress human NDRG1 at the transcriptional level. |
2(0,0,0,2) | Details |
| 18157634 | Mikheev AM, Mikheeva SA, Maxwell JP, Rivo JV, Rostomily R, Swisshelm K, Zarbl H: Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. Breast Cancer Res Treat. 2008 Nov;112(2):263-73. Epub 2007 Dec 22. Consistent with the results of these transient transfection assays, we were unable to demonstrate the expected beta-catenin dependent, TCF/Lef mediated inhibition of cyclin D1 and c-myc gene transcription in breast cells overexpressing DKK-1. |
1(0,0,0,1) | Details |
| 18579786 | Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M: The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8866-71. Epub 2008 Jun 25. We also show that there is a miR-34 target site within the 3' UTR of c-myc mRNA and that promoter dependency is also true for this endogenous 3' UTR. |
1(0,0,0,1) | Details |