Protein Information

Name cholesterol sulfotransferase
Synonyms Alcohol sulfotransferase; ST2; Estrogen sulfotransferase; Alcohol/hydroxysteroid sulfotransferase; Bile salt sulfotransferase; DHEA sulphotransferase; DHEA ST; Dehydroepiandrosterone sulfotransferase…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18935790 Huang YH, Tsai MM, Lin KH: Thyroid hormone dependent regulation of target genes and their physiological significance. Chang Gung Med J. 2008 Jul-Aug;31(4):325-34.

The data demonstrated that approximately 149 genes represented were positively regulated by T3, including fibrinogen, transferrin, fibronectin (FN), androgen receptor (AR)-associated protein (ARA70), and dehydroepiandrosterone sulfotransferase family 1A member 2 (SULT2A1).
The protein synthesis inhibitor, cycloheximide was used to determine whether the regulation was direct or indirect.
1(0,0,0,1) Details
16469813 Huang YH, Lee CY, Tai PJ, Yen CC, Liao CY, Chen WJ, Liao CJ, Cheng WL, Chen RN, Wu SM, Wang CS, Lin KH: Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones. Endocrinology. 2006 May;147(5):2481-9. Epub 2006 Feb 9.

Cycloheximide inhibited T (3)-induced SULT2A1 expression, suggesting that regulation was indirect.
91(1,1,1,11) Details
16150827 Jiang YJ, Kim P, Elias PM, Feingold KR: LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes. J Lipid Res. 2005 Dec;46(12):2657-66. Epub 2005 Sep 8.

In addition, cycloheximide almost completely blocks the ciglitazone-induced increase in SULT2B1b mRNA, suggesting that the transcription of SULTB1b mRNA is dependent on new protein synthesis.
3(0,0,0,3) Details