| Name | P glycoprotein |
|---|---|
| Synonyms | ABC20; MDR1; ABCB 1; ABCB1; ATP binding cassette sub family B member 1; CD243; CD243 antigen; CLCS… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19414624 | Fan J, Liu S, Du Y, Morrison J, Shipman R, Pang KS: Up-regulation of transporters and enzymes by the receptor ligands, 1alpha,25- and analogs, in the Caco-2 cell monolayer. J Pharmacol Exp Ther. 2009 Aug;330(2):389-402. Epub 2009 May 4. The mRNA and protein expressions of the apical sodium-dependent bile acid transporter, oligopeptide transporter 1, multidrug resistance-associated protein (MRP) 3, and sulfotransferase 1E1 remained unchanged with 1,25 (OH)(2) D (3) treatment, whereas those for CYP3A4, multidrug resistance protein 1, and MRP2 were significantly increased (P < 0.05). 1,25 (OH)(2) D (3) treatment significantly enhanced MRP4 protein expression by increasing protein stability without affecting mRNA expression, as confirmed in cycloheximide experiments. |
33(0,1,1,3) | Details |
| 16465293 | Belloc F, Cotteret S, Labroille G, Schmit V, Jaloustre C, Dumain P, Durrieu F, Reiffers J, Boisseau MR, Bernard P, Lacombe F: Bcr-abl translocation can occur during the induction of multidrug resistance and confers apoptosis resistance on myeloid leukemic cell lines. Cell Death Differ. 1997 Dec;4(8):806-14. Apoptosis was studied in parental and mdr-1 expressing U937, HL60 and K562 myeloid leukemic cell lines using mdr unrelated inducers of apoptosis such as Ara-C, cycloheximide, serum deprivation, monensin and UV irradiation. |
10(0,0,1,5) | Details |
| 17122416 | Fu D, Roufogalis BD: Actin disruption inhibits endosomal traffic of P-glycoprotein-EGFP and resistance to daunorubicin accumulation. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1543-52. Epub 2006 Nov 22. |
9(0,0,0,9) | Details |
| 15796929 | Yamamoto S, Hiraga K, Abiko A, Hamanaka N, Oda K: A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2005 May 6;330(2):622-8. Pdr5p in Saccharomyces cerevisiae is a functional homologue of mammalian P-glycoprotein implicated in multidrug resistance (MDR). A non-toxic concentration of the isonitrile (41.5 microg/ml, 255 microM) inhibited Pdr5p-mediated efflux of cycloheximide or cerulenin in Pdr5p-overexpressing cells. |
1(0,0,0,1) | Details |
| 19470507 | Sharma M, Manoharlal R, Shukla S, Puri N, Prasad T, Ambudkar SV, Prasad R: modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Antimicrob Agents Chemother. 2009 Aug;53(8):3256-65. Epub 2009 May 26. (CUR), a natural product of from rhizomes of longa, is a known agent of reversal of drug resistance phenotypes in cancer cells overexpressing ATP-binding cassette (ABC) transporters, viz., ABCB1, ABCG2, and ABCC1. Drug susceptibility testing of ABC protein-expressing cells by spot assays and checkerboard tests revealed that CUR was selectively synergistic with drug substrates such as R6G, ketoconazole, itraconazole, and miconazole but not with fluconazole, voriconazole, anisomycin, cycloheximide, or FK520. |
1(0,0,0,1) | Details |
| 16475832 | Shukla S, Rai V, Banerjee D, Prasad R: Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis. Biochemistry. 2006 Feb 21;45(7):2425-35. Unlike its close homologue human P-gp/MDR1, purified Cdr1p only moderately displayed drug stimulated ATPase activity. |
1(0,0,0,1) | Details |
| 17013532 | Duraj J, Bodo J, Sulikova M, Rauko P, Sedlak J: Diverse sensitization to apoptosis induced by anticancer drugs in sensitive and resistant leukemia cells. Neoplasma. 2006;53(5):384-92. Cell cycle analysis in sensitive promyelocytic leukemia HL60 cell line and its multidrug-resistant variant HL60/VCR (P-gp positive) treated with RES resulted in cell cycle arrest in S-phase in both cell variants. Flow cytometry measurements showed diverse activities of RES in combination with anticancer drugs doxorubicin (DOX), cycloheximide (CHX), busulfan (BUS), gemcitabine (GEM) and paclitaxel (PTX), in some cases resulting in apoptosis induction, preferentially at the expense of S-phase. |
1(0,0,0,1) | Details |