| Name | PUMA |
|---|---|
| Synonyms | BBC 3; BBC3; BCL2 binding component 3; Bcl 2 binding component 3; JFY 1; JFY1; PUMA; PUMA/JFY1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19439449 | Zhang Y, Xing D, Liu L: PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Mol Biol Cell. 2009 Jul;20(13):3077-87. Epub 2009 May 13. In addition, pifithrin-alpha (a p53 inhibitor) and cycloheximide (a protein synthesis inhibitor) could inhibit PUMA-mediated Bax translocation and cell apoptosis. |
88(1,1,1,8) | Details |
| 17363499 | Ding WX, Ni HM, Chen X, Yu J, Zhang L, Yin XM: A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. Mol Cancer Ther. 2007 Mar;6(3):1062-9. Consistently, inhibition of translation by cycloheximide could also effectively abolish the accumulation of p53 and PUMA and suppress MG132-induced Bax activation and apoptosis. |
35(0,1,1,5) | Details |
| 17879164 | Shaltouki A, Freer M, Mei Y, Weyman CM: Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis. 2007 Dec;12(12):2143-54. Inclusion of cycloheximide inhibits the release of cytochrome C, the activation of caspase 9 and apoptosis. |
5(0,0,0,5) | Details |
| 18657356 | Wu Y, Xing D, Liu L, Gao B: Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathways. Cancer Lett. 2008 Nov 28;271(2):231-9. Epub 2008 Jul 25. Then using CHX (cycloheximide) to prevent new protein expression in response to p53, we also find that Bax translocation and cell death by UV irradiation are delayed. Finally, we observe that Pifithrin-alpha and CHX effectively inhibit PUMA expression by UV irradiation. |
2(0,0,0,2) | Details |
| 18941459 | Diallo JS, Betton B, Parent N, Peant B, Lessard L, Le Page C, Bertrand R, Mes-Masson AM, Saad F: Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors. Br J Cancer. 2008 Nov 18;99(10):1613-22. Epub 2008 Oct 21. Treatment with IP6 also leads to increased protein levels of PUMA, BIK/NBK and NOXA between 4 and 8 h of treatment and decreased levels of MCL-1 and BCL-2 after 24 h. Although blocking transcription using actinomycin D does not modulate PC3 cell sensitivity to IP6, inhibition of protein translation using cycloheximide has a significant protective effect. |
1(0,0,0,1) | Details |