| Name | S1P |
|---|---|
| Synonyms | MBTPS 1; MBTPS1; MBTPS1 protein; Membrane bound transcription factor site 1 protease precursor; Membrane bound transcription factor site 1 protease; PCSK 8; PCSK8; S1P… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15855330 | Mastrandrea LD, Sessanna SM, Laychock SG: kinase activity and production in rat pancreatic islets and INS-1 cells: response to cytokines. Diabetes. 2005 May;54(5):1429-36. Cytokines increased endogenous S1P biosynthesis in 32P (i)-prelabeled INS-1 cells, and cycloheximide inhibited the response after 8 h, suggesting that protein synthesis mediated the response. |
34(0,1,1,4) | Details |
| 18654850 | Greenspon J, Li R, Xiao L, Rao JN, Marasa BS, Strauch ED, Wang JY, Turner DJ: protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. Dig Dis Sci. 2009 Mar;54(3):499-510. Epub 2008 Jul 25. SUMMARY: (S1P) has been shown to play a critical role in cellular protection to otherwise lethal stimuli in several nonintestinal tissues. |
5(0,0,0,5) | Details |
| 16571380 | Huwiler A, Doll F, Ren S, Klawitter S, Greening A, Romer I, Bubnova S, Reinsberg L, Pfeilschifter J: increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochim Biophys Acta. 2006 Mar;1761(3):367-76. Epub 2006 Mar 10. (S1P) is a potent mitogenic signal generated from by the action of kinases (SKs). The increased SK-1 protein expression is due to stimulated de novo synthesis since cycloheximide inhibited the delayed SK-1 protein upregulation. |
1(0,0,0,1) | Details |
| 16691509 | Saha B, Singh SK, Sarkar C, Mallick S, Bera R, Bhadra R: Transcriptional activation of tyrosinase gene by human placental sphingolipid. Glycoconj J. 2006 May;23(3-4):259-68. Recently sphingosylphosphorylcholine (SPC), (S1P), and C2- (C2- sphingolipid containing are emerging as melanogenic regulators. Actinomycin D and cycloheximide, inhibitors of transcription and translation, respectively, inhibited PSL-induced tyrosinase activity and its protein expression showing decrease in melanogenesis, correspondingly. |
1(0,0,0,1) | Details |
| 19683494 | Descot A, Hoffmann R, Shaposhnikov D, Reschke M, Ullrich A, Posern G: Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. Mol Cell. 2009 Aug 14;35(3):291-304. Upregulation of Mig6 by lipid agonists such as LPA and S1P or actin drugs involved MAL and correlated with decreased activation of EGFR, MAPK/Erk, and c-fos. |
1(0,0,0,1) | Details |