Protein Information

Name adipose triglyceride lipase
Synonyms 1110001C14Rik; ATGL; Adipose triglyceride lipase; Desnutrin; FP17548; PNPLA 2; Patatin like phospholipase domain containing 2…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18643838 Liu LF, Purushotham A, Wendel AA, Koba K, DeIuliis J, Lee K, Belury MA: Regulation of adipose triglyceride lipase by rosiglitazone. . Diabetes Obes Metab. 2009 Feb;11(2):131-42. Epub 2008 Jul 17.

Finally, we found that rosiglitazone increased ATGL mRNA levels in 3T3-L1 adipocytes in the presence of cycloheximide, an inhibitor of protein synthesis, suggesting that rosiglitazone regulation of ATGL occurs at the transcriptional level.
8(0,0,0,8) Details
17848638 Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS: PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1736-45. Epub 2007 Sep 11.

Rosiglitazone-mediated induction of ATGL mRNA is rapid and is not inhibited by the protein synthesis inhibitor cycloheximide, indicating that intervening protein synthesis is not required for this effect.
7(0,0,0,7) Details