Protein Information

Name interleukin 7
Synonyms IL 7; IL7; Interleukin 7; Interleukin 7 precursor; LP 1; Lymphopoietin 1; Pre B Cell factor; Interleukin 7s…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
19248116 Yammani RR, Long D, Loeser RF: Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum. 2009 Mar;60(3):792-800.

Pretreatment of chondrocytes with a JAK-3 inhibitor or with cycloheximide blocked the IL-7-mediated secretion of S100A4, but pretreatment with brefeldin A did not.
86(1,1,1,6) Details
16425129 Sasson SC, Zaunders JJ, Zanetti G, King EM, Merlin KM, Smith DE, Stanley KK, Cooper DA, Kelleher AD: Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis. 2006 Feb 15;193(4):505-14. Epub 2006 Jan 17.

The effects of IL-7 and cycloheximide on IL-7R expression by peripheral blood mononuclear cells were examined in vitro.
11(0,0,1,6) Details
17568689 Shibata H, Tani-ichi S, Lee HC, Maki K, Ikuta K: Induction of the IL-7 receptor alpha chain in mouse peripheral B cells by glucocorticoids. Immunol Lett. 2007 Jul 31;111(1):45-50. Epub 2007 May 30.

This effect does not require de novo protein synthesis, because a protein synthesis inhibitor, cycloheximide, does not block the transcription.
3(0,0,0,3) Details