Protein Information

Name IL 21
Synonyms IL 10 related T cell derived inducible factor; IL 21; IL 22; IL21; IL D110; IL TIF; IL22; ILD110…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17673207 Rahman M, Nara H, Onoda T, Araki A, Li J, Hoshino T, Asao H: Cloning and characterization of an isoform of interleukin-21. . FEBS Lett. 2007 Aug 21;581(21):4001-9. Epub 2007 Jul 25.

However, cycloheximide treatment partially blocked the upregulation of IL-21iso mRNA in activated T cells while little affected the IL-21 mRNA expression suggesting that de novo protein synthesis is required for the full expression of IL-21iso transcript.
88(1,1,1,8) Details
19699525 Harashima A, Toraya T, Okochi A, Yamamoto M, Suzuki M, Otani T, Inoue T, Tsuji-Takayama K, Sugimoto A, Takeuchi M, Yamasaki F, Nakamura S, Kibata M: Interleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells. Mol Immunol. 2009 Oct;46(16):3310-9. Epub 2009 Aug 21.

Interestingly, IL-8 mRNA was induced by cycloheximide treatment and RANTES showed reduced mRNA but increased protein expression by antibody stimulation.
Twelve genes, including IL-2, IL-3, IL-4, IL-22, CCL1, and lymphotactin, were categorized as antibody stimulation-responsive but stromal cell-non-responsive.
1(0,0,0,1) Details