Protein Information

Name casein
Synonyms Alpha; Alpha s1 casein; Alpha s1 casein precursor; CASA; CSN 1; CSN1; CSN1S1; Casein…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
16325375 Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, Sun Z, He F: CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal. 2006 Sep;18(9):1386-95. Epub 2005 Dec 1.

CKIP-1 (casein kinase-2 interacting protein-1) is implicated in muscle differentiation, regulation of cell morphology and actin cytoskeleton.
Here, we report that overexpression of CKIP-1 in SK-BR-3 breast cancer cells prevents p53 degradation induced by cycloheximide treatment through increase of p53 N-terminal Ser-15 phosphorylation level.
1(0,0,0,1) Details
18343803 Oliver BG, Silver PM, White TC: Polyene susceptibility is dependent on nitrogen source in the opportunistic pathogen Candida albicans. J Antimicrob Chemother. 2008 Jun;61(6):1302-8. Epub 2008 Mar 13.

METHODS: Candida albicans was grown in protein [bovine serum albumin (BSA) or casein (CSN)] as a sole nitrogen source, in ammonium sulphate (AS) as a nitrogen source, or in both protein and AS.
Similar results were observed for cycloheximide, but not for fluconazole or caspofungin, and were observed for many C. albicans clinical isolates.
1(0,0,0,1) Details
15757501 Hattori H, Imai H, Hanamoto A, Furuhama K, Nakagawa Y: Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophils. Biochem J. 2005 Jul 15;389(Pt 2):279-87.

Up-regulation of PHGPx mRNA was attenuated by cycloheximide, a protein synthesis inhibitor, and this effect was cancelled by culturing the cells in the conditioned medium of the cultured casein-induced PMNs.
90(1,1,2,5) Details
19663814 Choi C, Lee J, Lim C, Jang D, Choe J: The DOUBLETIME protein kinase regulates phosphorylation of the Drosophila PDP1epsilon. J Neurochem. 2009 Oct;111(1):264-73. Epub 2009 Aug 5.


The kinase DOUBLETIME (DBT), a Drosophila ortholog of mammalian casein kinase Iepsilon, regulates circadian phosphorylation of two essential clock proteins, PERIOD and dCLOCK.
1(0,0,0,1) Details
18777141 Antony-Babu S, Goodfellow M: Biosystematics of alkaliphilic streptomycetes isolated from seven locations across a beach and dune sand system. Antonie Van Leeuwenhoek. 2008 Nov;94(4):581-91. Epub 2008 Sep 7.

Alkaliphilic streptomycetes were isolated from composite sand samples collected from six out of seven locations across a beach and dune sand system using starch-casein-nitrate agar supplemented with cycloheximide and buffered to pH 10.5.
6(0,0,1,1) Details
17419942 Miller G, El-Guindy A, Countryman J, Ye J, Gradoville L: Lytic cycle switches of oncogenic human gammaherpesviruses. Adv Cancer Res. 2007;97:81-109.


We show that phosphorylation of ZEBRA at its casein kinase 2 (CK2) site separates these two functions.
1(0,0,0,1) Details