| Name | leptin |
|---|---|
| Synonyms | LEP; Leptin; Leptin precursor; OB; OBS; Obese protein; Obesity factor; leptin (murine obesity homolog)… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16738357 | Lee MJ, Fried SK: Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue. J Lipid Res. 2006 Sep;47(9):1984-93. Epub 2006 May 31. |
8(0,0,0,8) | Details |
| 19254925 | Maeda T, Horiuchi N: suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. J Biochem. 2009 Jun;145(6):771-81. Epub 2009 Mar 2. inhibition of leptin gene transcription was not abrogated by pre-treatment with cycloheximide, an inhibitor of protein synthesis. |
8(0,0,0,8) | Details |
| 16609702 | Cammisotto PG, Bukowiecki LJ, Deshaies Y, Bendayan M: Leptin biosynthetic pathway in white adipocytes. . Biochem Cell Biol. 2006 Apr;84(2):207-14. These stimulating effects were abolished by cycloheximide and brefeldin A. |
7(0,0,0,7) | Details |
| 15585586 | Ricci MR, Lee MJ, Russell CD, Wang Y, Sullivan S, Schneider SH, Brolin RE, Fried SK: Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E798-804. Epub 2004 Dec 7. Inhibition of protein synthesis with cycloheximide did not block the effect of Iso on leptin release from human adipose tissue, suggesting that the Iso effect is independent of leptin synthesis. |
7(0,0,0,7) | Details |
| 16493119 | Giovambattista A, Piermaria J, Suescun MO, Calandra RS, Gaillard RC, Spinedi E: Direct effect of ghrelin on leptin production by cultured rat white adipocytes. Obesity (Silver Spring). 2006 Jan;14(1):19-27. Adipocytes were also incubated with ghrelin and inhibitors either of RNA (actinomycin D) or protein synthesis (cycloheximide) or with several concentrations (10 to 1000 nM) of a specific ghrelin antagonist. |
5(0,0,0,5) | Details |
| 18501893 | Zeigerer A, Rodeheffer MS, McGraw TE, Friedman JM: Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. Exp Cell Res. 2008 Jul 1;314(11-12):2249-56. Epub 2008 Apr 12. |
5(0,0,0,5) | Details |
| 17070518 | Hosoi T, Matsunami N, Nagahama T, Okuma Y, Ozawa K, Takizawa T, Nomura Y: 2-Aminopurine inhibits leptin receptor signal transduction. Eur J Pharmacol. 2006 Dec 28;553(1-3):61-6. Epub 2006 Sep 28. Leptin is an important circulating signal for the regulation of food intake and body weight. The inhibitory effect of 2-AP was not mediated by newly synthesized protein because the inhibitory effect of 2-AP on leptin-induced STAT3 activation was not abrogated in the presence of the protein synthesis inhibitor cycloheximide. |
4(0,0,0,4) | Details |
| 18701813 | Peters EE, Towler KL, Mason DR, Evans JJ: Effects of galanin and leptin on gonadotropin-releasing hormone-stimulated luteinizing hormone release from the pituitary. Neuroendocrinology. 2009;89(1):18-26. Epub 2008 Aug 14. The effect of inhibiting protein synthesis, with cycloheximide, was also studied under these conditions. |
3(0,0,0,3) | Details |
| 17848638 | Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS: PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1736-45. Epub 2007 Sep 11. -mediated induction of ATGL mRNA is rapid and is not inhibited by the protein synthesis inhibitor cycloheximide, indicating that intervening protein synthesis is not required for this effect. In vivo, ATGL mRNA and protein are increased by treatment in white and brown adipose tissue of mice with and without obesity due to high-fat diet or leptin deficiency. |
1(0,0,0,1) | Details |