Protein Information

Name HDAC4
Synonyms HA6116; HD4; HDAC 4; HDAC A; HDAC4; HDACA; Histone deacetylase 4; Histone deacetylase A…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
18632985 Wilson AJ, Byun DS, Nasser S, Murray LB, Ayyanar K, Arango D, Figueroa M, Melnick A, Kao GD, Augenlicht LH, Mariadason JM: HDAC4 promotes growth of colon cancer cells via repression of p21. Mol Biol Cell. 2008 Oct;19(10):4062-75. Epub 2008 Jul 16.

Conversely, overexpression of HDAC4 repressed p21 promoter activity. p21 was likely a direct target of HDAC4, because HDAC4 down-regulation increased p21 mRNA when protein synthesis was inhibited by cycloheximide.
41(0,1,1,11) Details