Protein Information

Name gelsolin
Synonyms ADF; Actin depolymerizing factor; AGEL; Brevin; GSN; Gelsolin; Gelsolin precursor; Brevins…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
20339915 Ji L, Chauhan A, Chauhan V: Calcium Induces Expression of Cytoplasmic Gelsolin in SH-SY5Y and HEK-293 Cells. Neurochem Res. 2010 Mar 26.

Calcium-mediated up-regulation of c-gelsolin was inhibited by cycloheximide (a general inhibitor of protein synthesis).
88(1,1,1,8) Details
20157239 Ji L, Chauhan A, Chauhan V: Upregulation of cytoplasmic gelsolin, an amyloid-beta-binding protein, under oxidative stress conditions: involvement of protein kinase C. J Alzheimers Dis. 2010 Jan;19(3):829-38.

Pretreatment of cells with cycloheximide (an inhibitor of protein synthesis) resulted in significant inhibition of H (2) O (2) induced c-gelsolin expression, suggesting the possible de novo synthesis of c-gelsolin in cells.
8(0,0,0,8) Details
19920324 Ji L, Chauhan A, Chauhan V: Upregulation of Cytoplasmic Gelsolin, an Amyloid-beta-Binding Protein, Under Oxidative Stress Conditions: Involvement of Protein Kinase C. J Alzheimers Dis. 2009 Nov 17.

Pretreatment of cells with cycloheximide (an inhibitor of protein synthesis) resulted in significant inhibition of H _2 O _2 -induced c-gelsolin expression, suggesting the possible de novo synthesis of c-gelsolin in cells.
8(0,0,0,8) Details
16409300 Binet F, Cavalli H, Moisan E, Girard D: Arsenic trioxide (AT) is a novel human neutrophil pro-apoptotic agent: effects of catalase on AT-induced apoptosis, degradation of cytoskeletal proteins and de novo protein synthesis. Br J Haematol. 2006 Feb;132(3):349-58.

Cycloheximide partially reversed AT-induced apoptosis.
Herein, we found that AT-induced neutrophil apoptosis and gelsolin degradation via caspases.
2(0,0,0,2) Details