| Name | WAF1 |
|---|---|
| Synonyms | CAP20; CDKN1A; Cip1; PIC 1; PIC1; P21; CDK interacting protein 1; CDK interaction protein 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15574338 | Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM: N-acetylation and ubiquitin-independent proteasomal degradation of p21 (Cip1). Mol Cell. 2004 Dec 3;16(5):839-47. |
2(0,0,0,2) | Details |
| 15870436 | Van Dross R, Yao S, Asad S, Westlake G, Mays DJ, Barquero L, Duell S, Pietenpol JA, Browning PJ: Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells. J Natl Cancer Inst. 2005 May 4;97(9):656-66. METHODS: We used immunoprecipitation with K-cyclin antibodies to examine the association of K-cyclin with cdk2, cdk6, p21Cip1, and p27Kip1 proteins in BC3 cells. The half-life of K-cyclin and cyclin D2 proteins was determined by blocking protein synthesis with cycloheximide and measuring proteins in cell lysates by western blot analysis. |
2(0,0,0,2) | Details |
| 15728246 | Gugliesi F, Mondini M, Ravera R, Robotti A, de Andrea M, Gribaudo G, Gariglio M, Landolfo S: Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J Leukoc Biol. 2005 May;77(5):820-9. Epub 2005 Feb 22. Moreover, binding to IFI16 resulted in its transcriptional activation as shown by an increase in the activity of a reporter gene driven by p53-responsive sequences derived from the p21 (WAF1) promoter, along with an increase in the p21 mRNA and protein levels. To investigate the mechanism of IFI16 accumulation, cells were incubated for 6 h in the presence of H2O2 or IFN-beta, and then cycloheximide was added to inhibit further protein synthesis. |
1(0,0,0,1) | Details |
| 16087277 | Zupanska A, Dziembowska M, Ellert-Miklaszewska A, Gaweda-Walerych K, Kaminska B: Cyclosporine a induces growth arrest or programmed cell death of human glioma cells. Neurochem Int. 2005 Nov;47(6):430-41. In studied glioma cells, an accumulation of p21Cip1/Waf1 protein, a cell cycle inhibitor, was observed following CsA treatment, even in the absence of functional p53 tumour suppressor. |
1(0,0,0,1) | Details |
| 18690848 | Clark DW, Mitra A, Fillmore RA, Jiang WG, Samant RS, Fodstad O, Shevde LA: NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress. Curr Cancer Drug Targets. 2008 Aug;8(5):421-30. An increase in NUPR1 expression has been seen with serum starvation and in response to compounds such as cycloheximide, and staurosporine. This work investigates the nature of the relationship between NUPR1 and the cdk-inhibitor p21 (Waf1/Cip1) expression. |
1(0,0,0,1) | Details |
| 17938263 | Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R: p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol Cancer Ther. 2007 Oct;6(10):2696-707. Next, studies were done to examine mechanisms of their induction where cycloheximide-chase experiments showed that silibinin increases p21 and p27 protein half-life. |
0(0,0,0,0) | Details |
| 17297446 | Meng LH, Kohn KW, Pommier Y: Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene. 2007 Jul 19;26(33):4806-16. Epub 2007 Feb 12. |
8(0,0,0,8) | Details |
| 19136059 | Bhattacharya S, Ray RM, Johnson LR: Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal. 2009 Apr;21(4):509-22. Epub 2008 Dec 24. Our data show that camptothecin (CPT)-induced apoptosis correlated with increased p53, p21Cip1, and Mdm2 protein levels, with a simultaneous increase in ATR Ser428, p53 Ser15 and Mdm2 Ser166 phosphorylation in IEC-6 cells. The translation inhibitor, cycloheximide (CHX), prevented CPT-induced apoptosis. |
4(0,0,0,4) | Details |