| Name | calmodulin |
|---|---|
| Synonyms | CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16547004 | Edlich F, Weiwad M, Wildemann D, Jarczowski F, Kilka S, Moutty MC, Jahreis G, Lucke C, Schmidt W, Striggow F, Fischer G: The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl) cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J Biol Chem. 2006 May 26;281(21):14961-70. Epub 2006 Mar 17. Here we show that neurotrophic FKBP ligands, such as GPI1046 and N-[methyl (ethoxycarbonyl)] cycloheximide, inhibit the calmodulin/Ca (2+) (CaM/Ca (2+))-regulated FKBP38 with up to 80-fold higher affinity than FKBP12. |
81(1,1,1,1) | Details |
| 17647100 | Takadera T, Ohyashiki T: Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. Cell Mol Neurobiol. 2007 Sep;27(6):783-90. Epub 2007 Jul 24. In addition, nerve growth factor and cycloheximide, a protein synthesis inhibitor, completely blocked cell death. |
7(0,0,0,7) | Details |
| 20339118 | Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM: Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via /Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells. Circ Res. 2010 Mar 25. Effects were inhibited by actinomycin D and cycloheximide and blunted by calmidazolium and low extracellular Ca (2+) ([Ca (2+)] e). |
5(0,0,0,5) | Details |
| 16606372 | Cossenza M, Cadilhe DV, Coutinho RN, Paes-de-Carvalho R: Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of production. J Neurochem. 2006 Jun;97(5):1481-93. Epub 2006 Apr 10. This effect seems to be mediated by activation of eEF2 kinase, a /calmodulin-dependent enzyme which specifically phosphorylates and blocks eEF2. Although L-[3H] uptake measured in cultured chick retina cells incubated in the presence of cycloheximide (CHX, a protein synthesis inhibitor) was inhibited approximately 75% at equilibrium, quantitative thin-layer chromatography analysis showed that free intracellular L-[3H] was six times higher in CHX-treated than in control cultures. |
1(0,0,0,1) | Details |
| 19371335 | Kang L, Zheng MQ, Morishima M, Wang Y, Kaku T, Ono K: Bepridil up-regulates cardiac Na+ channels as a long-term effect by blunting proteasome signals through inhibition of calmodulin activity. Br J Pharmacol. 2009 Jun;157(3):404-14. Epub 2009 Apr 9. During inhibition of protein synthesis by cycloheximide, the I (Na) increase due to bepridil was larger than the increase without cycloheximide. |
2(0,0,0,2) | Details |
| 19463893 | Claasen AM, Guevremont D, Mason-Parker SE, Bourne K, Tate WP, Abraham WC, Williams JM: Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neurosci Lett. 2009 Aug 21;460(1):92-6. Epub 2009 May 20. This was dose-dependent and blocked completely by inhibitors of protein synthesis (cycloheximide) and of -dependent protein kinase (KT5823). Inhibitors of /calmodulin-dependent protein kinases (KN62) and mitogen-activated protein kinase (PD98059) partially blocked the response. |
1(0,0,0,1) | Details |
| 18614030 | Park S, Park JM, Kim S, Kim JA, Shepherd JD, Smith-Hicks CL, Chowdhury S, Kaufmann W, Kuhl D, Ryazanov AG, Huganir RL, Linden DJ, Worley PF: Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron. 2008 Jul 10;59(1):70-83. The increase in Arc/Arg3.1 translation requires eEF2K, a Ca (2+)/calmodulin-dependent kinase that binds mGluR and dissociates upon mGluR activation, whereupon it phosphorylates eEF2. |
1(0,0,0,1) | Details |