| Name | human ether a go go related gene |
|---|---|
| Synonyms | HERG; Voltage gated potassium channel; ERG; ERG1; Eag homolog; Eag related protein 1; Ether a go go related gene potassium channel 1; Ether a go go related protein 1… |
| Name | cycloheximide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18599551 | Wu ZY, Chen K, Haendler B, McDonald TV, Bian JS: Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-a-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2. Endocrinology. 2008 Oct;149(10):5061-9. Epub 2008 Jul 3. Consistently, the cycloheximide-based protein chase study showed that 5alpha-DHT prolonged HERG protein half-life. 5alpha-DHT/AR45 signaling induced phosphorylation of ERK1/2. |
39(0,1,1,9) | Details |
| 17576861 | Gong Q, Zhang L, Vincent GM, Horne BD, Zhou Z: Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome. Circulation. 2007 Jul 3;116(1):17-24. Epub 2007 Jun 18. BACKGROUND: Long-QT syndrome type 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG). Treatment with the protein synthesis inhibitor cycloheximide or RNA interference-mediated knockdown of the Upf1 protein resulted in the restoration of mutant mRNA to levels comparable to that of the wild-type minigene, suggesting that hERG nonsense mutations are subject to nonsense-mediated mRNA decay. |
5(0,0,0,5) | Details |
| 20139709 | Vanoye CG, Welch RC, Tian C, Sanders CR, George AL Jr: KCNQ1/KCNE1 assembly, co-translation not required. Channels. 2010 Mar 6;4(2). Voltage-gated potassium channels are often assembled with accessory proteins that increase their functional diversity. Incubation of KCNQ1-expressing oocytes with cycloheximide did not prevent I (Ks) expression following prKCNE1 injection. |
1(0,0,0,1) | Details |