Protein Information

Name activin A
Synonyms Activin A; EDF; Activin A B; Activin beta A; Activin beta A chain; Ed differentiation factor; Erythroid differentiation protein; FRP…

Compound Information

Name cycloheximide
CAS

Reference List

PubMed Abstract RScore(About this table)
17512555 Kawabata N, Kamiya N, Suzuki N, Matsumoto M, Takagi M: Changes in extracellular activin A:follistatin ratio during differentiation of a mesenchymal progenitor cell line, ROB-C26 into osteoblasts and adipocytes. Life Sci. 2007 Jun 13;81(1):8-18. Epub 2007 Apr 21.

Cycloheximide pre-treatment indicated that FS and activin A expressions appear to be the direct target of BMP-2 and Dex signaling.
37(0,1,1,7) Details
19339694 Salogni L, Musso T, Bosisio D, Mirolo M, Jala VR, Haribabu B, Locati M, Sozzani S: Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood. 2009 Jun 4;113(23):5848-56. Epub 2009 Apr 1.

Conversely, activin A was not active on plasmacytoid dendritic cells (DCs) or mature myeloid DCs. iDC migration to activin A was phosphatidylinositol 3-kinase gamma-dependent, Bordetella pertussis toxin- and cycloheximide-sensitive, and was inhibited by M3, a viral-encoded chemokine-binding protein.
7(0,0,0,7) Details
17951260 Kipp JL, Kilen SM, Woodruff TK, Mayo KE: Activin regulates estrogen receptor gene expression in the mouse ovary. . J Biol Chem. 2007 Dec 14;282(50):36755-65. Epub 2007 Oct 19.

Activin, a member of the transforming growth factor-beta superfamily, is an important modulator of follicle-stimulating hormone synthesis and secretion in the pituitary and plays autocrine/paracrine roles in the regulation of ovarian follicle development.
Activin A stimulation of ER expression was a direct effect at the level of gene transcription, as it was not abolished by cycloheximide but was abolished by actinomycin D, and in transfected granulosa cells activin A stimulated ERalpha promoter activity.
4(0,0,0,4) Details